Alteplase
- Generic Name
- Alteplase
- Brand Names
- Activase, Cathflo, Cathflo Activase
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 105857-23-6
- Unique Ingredient Identifier
- 1RXS4UE564
- Background
Alteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent. It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots. In the absence of fibrin, the alteplase-mediated conversion of plasminogen is limited, thanks to the high affinity between alteplase and fibrin. Alteplase is a purified gl...
- Indication
Alteplase is indicated for the treatment of acute ischemic stroke (AIS) and for use in acute myocardial infarction (AMI) for the reduction of mortality and incidence of heart failure. Alteplase is also indicated for the lysis of acute massive pulmonary embolism, defined as acute pulmonary emboli obstructing blood flow to a lobe or multiple lung segments, and...
- Associated Conditions
- Acute Ischemic Stroke, Cardiac mortality, Heart Failure, Pulmonary Embolism Acute Massive, Central venous access device thrombosis
- Associated Therapies
- -
Prolonged Hemodialysis Catheter Survival With Copolymer Coating and Rt-PA
- First Posted Date
- 2012-08-22
- Last Posted Date
- 2012-08-22
- Lead Sponsor
- Centre Hospitalier du Centre du Valais
- Target Recruit Count
- 240
- Registration Number
- NCT01670474
- Locations
- 🇨🇭
Centre Hospitalier du Centre du Valais (CHCVs), Sion, Valais, Switzerland
Safety of Intravenous Thrombolytics in Stroke on Awakening
- First Posted Date
- 2012-07-18
- Last Posted Date
- 2017-04-17
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 20
- Registration Number
- NCT01643902
- Locations
- 🇺🇸
The Johns Hopkins Hospital, Baltimore, Maryland, United States
🇺🇸Johns Hopkins Bayview Medical Center, Baltimore, Maryland, United States
Intra-arterial Thrombolysis for Severe Recent Central Retinal Vein Occlusion
- Conditions
- Interventions
- First Posted Date
- 2012-04-20
- Last Posted Date
- 2018-08-06
- Lead Sponsor
- Weill Medical College of Cornell University
- Target Recruit Count
- 1
- Registration Number
- NCT01581411
- Locations
- 🇺🇸
Weill Cornell Medical College/ New York Presbyterian hospital, New York, New York, United States
Efficacy and Safety of MRI-based Thrombolysis in Wake-up Stroke
- First Posted Date
- 2012-02-02
- Last Posted Date
- 2018-10-11
- Lead Sponsor
- Universitätsklinikum Hamburg-Eppendorf
- Target Recruit Count
- 501
- Registration Number
- NCT01525290
- Locations
- 🇩🇪
Charite - Universitätsmedizin Berlin, Berlin, Germany
🇩🇪University Medical Center Hamburg-Eppendorf, Hamburg, Germany
🇬🇧University of Glasgow, Glasgow, United Kingdom
Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis- (ATTEST)
- First Posted Date
- 2011-11-17
- Last Posted Date
- 2018-08-03
- Lead Sponsor
- NHS Greater Glasgow and Clyde
- Target Recruit Count
- 104
- Registration Number
- NCT01472926
- Locations
- 🇬🇧
Southern General Hospital, Glasgow, Scotland, United Kingdom
Wake up Symptomatic Stroke - Benefit of Intravenous Clot Busters or Endovascular Intervention
- Conditions
- Interventions
- First Posted Date
- 2011-10-20
- Last Posted Date
- 2012-03-30
- Lead Sponsor
- Jacobs Neurological Institute
- Target Recruit Count
- 90
- Registration Number
- NCT01455935
- Locations
- 🇺🇸
Millard Fillmore Gates Circle Hospital, Buffalo, New York, United States
Comparison of Different TRansesophageal Echocardiography Guided thrOmbolytic Regimens for prosthetIc vAlve Thrombosis
- Conditions
- Interventions
- First Posted Date
- 2011-10-13
- Last Posted Date
- 2011-10-13
- Target Recruit Count
- 182
- Registration Number
- NCT01451320
- Locations
- 🇹🇷
Kosuyolu Kartal Heart Training and Research Hospital, Istanbul, Turkey
Intraventricular Tissue Plasminogen Activator (tPA) in the Management of Aneurysmal Subarachnoid Hemorrhage
- Conditions
- Interventions
- First Posted Date
- 2010-04-05
- Last Posted Date
- 2010-11-11
- Lead Sponsor
- University of Calgary
- Target Recruit Count
- 12
- Registration Number
- NCT01098890
- Locations
- 🇨🇦
Foothills Medical Center, Calgary, Alberta, Canada
New Acute Treatment for Stroke - The Effect of Remote PERconditioning
- Conditions
- Interventions
- First Posted Date
- 2009-09-14
- Last Posted Date
- 2011-06-23
- Lead Sponsor
- Aarhus University Hospital
- Target Recruit Count
- 120
- Registration Number
- NCT00975962
- Locations
- 🇩🇰
Department of Neurology, Aarhus University Hospital, Aarhus, Denmark
Study of the Combination Therapy of Rt-PA and Eptifibatide to Treat Acute Ischemic Stroke
- Conditions
- Interventions
- First Posted Date
- 2009-05-07
- Last Posted Date
- 2014-04-17
- Lead Sponsor
- University of Cincinnati
- Target Recruit Count
- 126
- Registration Number
- NCT00894803
- Locations
- 🇺🇸
West Virginia University Hospital, Morgantown, West Virginia, United States
🇺🇸UCLA Ronald Reagan Medical Center, Los Angeles, California, United States
🇺🇸UCLA Medical Center Santa Monica, Santa Monica, California, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.