Overview
Eltoprazine has been used in trials studying the treatment of Schizophrenia and Cognitive Impairment.
Indication
No indication information available.
Associated Conditions
No associated conditions information available.
Research Report
Eltoprazine (DB12883): A Comprehensive Report on a Multi-Target Serotonergic Agent's Pharmacological Profile, Clinical Development, and Troubled Trajectory
Executive Summary
Eltoprazine is a phenylpiperazine derivative with a complex and potentially valuable pharmacological profile, characterized primarily by its action as a partial agonist at serotonin 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor. Originally developed in the 1980s by Duphar and Solvay Pharmaceuticals as a "serenic" or anti-aggressive agent, its clinical journey has been marked by multiple strategic repositionings and significant corporate turmoil. Initial development for aggression was stymied by regulatory hurdles of the time, which viewed aggression as a symptom rather than a treatable disorder. Subsequently, the drug was explored for attention deficit hyperactivity disorder (ADHD) and cognitive impairment associated with schizophrenia (CIAS), with a Phase IIa trial in adult ADHD yielding positive results.
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2015/05/08 | Phase 2 | UNKNOWN | |||
2010/12/24 | Phase 2 | Completed |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| No FDA approvals found for this drug. | |||||
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| No TGA approvals found for this drug. | |||||
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