Acetylcysteine
- Generic Name
- Acetylcysteine
- Brand Names
- Acetadote
- Drug Type
- Small Molecule
- Chemical Formula
- C5H9NO3S
- CAS Number
- 616-91-1
- Unique Ingredient Identifier
- WYQ7N0BPYC
- Background
Acetylcysteine is an antioxidant and glutathione inducer indicated for mucolytic therapy and the treatment of acetaminophen overdose. Acetylcysteine has also been studied for a wide variety of off-label indications with mixed results.
Acetylcysteine was granted FDA approval on 14 September 1963.
- Indication
Acetylcysteine is indicated for mucolytic therapy and in the management of acetaminophen overdose.
- Associated Conditions
- Acetaminophen Overdose, Chronic Rhinitis, Corneal Diseases, Corneal ulceration, Crusting Rhinitis, Keratopathy, Rhinitis, Sinusitis, Vasomotor Rhinitis, Acute Rhinitis, Subacute Rhinitis
- Associated Therapies
- Airway secretion clearance therapy
Efficacy of N-Acetylcysteine in Treatment of Overt Diabetic Nephropathy
- Conditions
- Interventions
- First Posted Date
- 2007-11-12
- Last Posted Date
- 2007-11-12
- Lead Sponsor
- Shiraz University of Medical Sciences
- Target Recruit Count
- 60
- Registration Number
- NCT00556465
- Locations
- 🇮🇷
Mohammad mahdi sagheb, Shiraz, Fars, Iran, Islamic Republic of
An Open-Label Trial of N-Acetylcysteine in Cannabis Dependent Adolescents
- First Posted Date
- 2007-10-11
- Last Posted Date
- 2018-05-23
- Lead Sponsor
- Medical University of South Carolina
- Target Recruit Count
- 24
- Registration Number
- NCT00542750
- Locations
- 🇺🇸
Medical University of South Carolina, Charleston, South Carolina, United States
N-Acetylcysteine Augmentation in Treatment-Refractory Obsessive-Compulsive Disorder
- Conditions
- Interventions
- First Posted Date
- 2007-10-04
- Last Posted Date
- 2020-04-02
- Lead Sponsor
- Yale University
- Target Recruit Count
- 10
- Registration Number
- NCT00539513
N-Acetylcysteine in Adjunct to DBT for the Treatment of Self-Injurious Behavior in BPD
- Conditions
- Interventions
- First Posted Date
- 2007-10-04
- Last Posted Date
- 2020-04-15
- Lead Sponsor
- Yale University
- Target Recruit Count
- 6
- Registration Number
- NCT00539188
- Locations
- 🇺🇸
Yale OCD Research Clinic, New Haven, Connecticut, United States
N-Acetylcysteine in Heart Failure With Coexistent Chronic Renal Failure
- Conditions
- Interventions
- First Posted Date
- 2007-09-20
- Last Posted Date
- 2007-09-20
- Lead Sponsor
- Bayside Health
- Target Recruit Count
- 10
- Registration Number
- NCT00532688
- Locations
- 🇦🇺
Alfred Hospital, Melbourne, Victoria, Australia
Efficacy of Acetylcysteine in Patients Undergoing Surgery for Otosclerosis
- First Posted Date
- 2007-09-06
- Last Posted Date
- 2013-09-11
- Lead Sponsor
- Karolinska University Hospital
- Target Recruit Count
- 152
- Registration Number
- NCT00525551
- Locations
- 🇸🇪
Karolinska University Hospital Huddinge, Huddinge, Sweden
🇸🇪Karolinska University Hospital, Dept. of Otorhinolaryngology, Stockholm, Sweden
🇸🇪Academic Hospital, Uppsala, Sweden
Influence of N-Acetylcysteine on Morbidity, Oxygenation and Cytokine Levels in Partial or Total Esophagectomy for Cancer
- Conditions
- Interventions
- First Posted Date
- 2007-08-07
- Last Posted Date
- 2013-08-28
- Lead Sponsor
- University Hospital, Basel, Switzerland
- Target Recruit Count
- 29
- Registration Number
- NCT00512265
- Locations
- 🇨🇭
University Hospital Basel, Basel, Switzerland
🇨🇭Department of Surgery, Triemli Hospital, Zurich, Switzerland, Zurich, Switzerland
Effect of N-Acetylcysteine (NAC) on Creatinine in Chronic Kidney Disease
- First Posted Date
- 2007-07-25
- Last Posted Date
- 2009-04-15
- Lead Sponsor
- Lawson Health Research Institute
- Target Recruit Count
- 60
- Registration Number
- NCT00506506
- Locations
- 🇨🇦
London Health Sciences Centre, London, Ontario, Canada
Effect of N-Acetylcysteine on Residual Renal Function in Chronic Hemodialysis Patients
- Conditions
- First Posted Date
- 2007-07-25
- Last Posted Date
- 2007-07-25
- Lead Sponsor
- Assaf-Harofeh Medical Center
- Registration Number
- NCT00507052
- Locations
- 🇮🇱
Assaf Harofeh, Zerifin, Israel
The Effect of Administration on N-Acetylcysteine on Serum Creatinine Levels in Patients With Chronic Kidney Disease
- Conditions
- First Posted Date
- 2007-07-10
- Last Posted Date
- 2008-02-18
- Lead Sponsor
- University of Vermont
- Registration Number
- NCT00498342
- Locations
- 🇺🇸
University of Vermont /Fletcher Allen Health Care, Inc., Burlington, Vermont, United States
Drug Development Updates
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