Acetylcysteine
- Generic Name
- Acetylcysteine
- Brand Names
- Acetadote
- Drug Type
- Small Molecule
- Chemical Formula
- C5H9NO3S
- CAS Number
- 616-91-1
- Unique Ingredient Identifier
- WYQ7N0BPYC
- Background
Acetylcysteine is an antioxidant and glutathione inducer indicated for mucolytic therapy and the treatment of acetaminophen overdose. Acetylcysteine has also been studied for a wide variety of off-label indications with mixed results.
Acetylcysteine was granted FDA approval on 14 September 1963.
- Indication
Acetylcysteine is indicated for mucolytic therapy and in the management of acetaminophen overdose.
- Associated Conditions
- Acetaminophen Overdose, Chronic Rhinitis, Corneal Diseases, Corneal ulceration, Crusting Rhinitis, Keratopathy, Rhinitis, Sinusitis, Vasomotor Rhinitis, Acute Rhinitis, Subacute Rhinitis
- Associated Therapies
- Airway secretion clearance therapy
High-Dose N-Acetylcysteine in Cardiac Surgery
- Conditions
- First Posted Date
- 2006-06-01
- Last Posted Date
- 2009-07-07
- Lead Sponsor
- Austin Health
- Target Recruit Count
- 60
- Registration Number
- NCT00332631
- Locations
- 🇦🇺
Austin Hospital, Melbourne, Victoria, Australia
N-acetylcysteine in Non-Acetaminophen Pediatric Acute Liver Failure
- Conditions
- Interventions
- First Posted Date
- 2005-11-04
- Last Posted Date
- 2016-07-28
- Lead Sponsor
- University of Pittsburgh
- Target Recruit Count
- 184
- Registration Number
- NCT00248625
- Locations
- 🇺🇸
Children's Memorial Hospital, Chicago, Illinois, United States
🇬🇧King's College Hospital (London, UK), London, United Kingdom
🇺🇸Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, United States
The Effects of Acetylcysteine on Alleviating Damage of Oxidative Stress in Hemodialysis Patients
- First Posted Date
- 2005-11-02
- Last Posted Date
- 2006-10-18
- Lead Sponsor
- Far Eastern Memorial Hospital
- Registration Number
- NCT00247507
- Locations
- 🇨🇳
Far Eastern Memorial Hospital, Pan-Chiao, Taipei, Taiwan
Acetylcysteine, Mannitol, Combination Chemotherapy, and Sodium Thiosulfate in Treating Children With Malignant Brain Tumors
- First Posted Date
- 2005-10-13
- Last Posted Date
- 2017-04-21
- Lead Sponsor
- OHSU Knight Cancer Institute
- Target Recruit Count
- 2
- Registration Number
- NCT00238173
- Locations
- 🇺🇸
OHSU Knight Cancer Institute, Portland, Oregon, United States
Effectiveness of N-Acetylcysteine (NAC) in Treating Cocaine Dependent Individuals - 1
- Conditions
- Interventions
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2019-01-15
- Lead Sponsor
- Medical University of South Carolina
- Target Recruit Count
- 111
- Registration Number
- NCT00218491
- Locations
- 🇺🇸
Medical University of South Carolina, Charleston, South Carolina, United States
Acetylcysteine in the Prevention of Renal Failure After Bypass Surgery
- Conditions
- First Posted Date
- 2005-09-21
- Last Posted Date
- 2007-09-19
- Lead Sponsor
- Minneapolis Veterans Affairs Medical Center
- Target Recruit Count
- 102
- Registration Number
- NCT00211653
- Locations
- 🇺🇸
Veterans Affairs Medical Center, Minneapolis, Minnesota, United States
Effect of an Antioxidant on Cancer-Cachectic Patients Undergoing Exercise Training
- Conditions
- First Posted Date
- 2005-09-20
- Last Posted Date
- 2008-06-20
- Lead Sponsor
- German Cancer Research Center
- Target Recruit Count
- 60
- Registration Number
- NCT00196885
- Locations
- 🇩🇪
German Cancer Research Center, D020, Heidelberg, Baden-Württemberg, Germany
N-Acetylcysteine for Preventing Renal Injury After Cardiac Surgery
- Conditions
- Interventions
- First Posted Date
- 2005-09-16
- Last Posted Date
- 2011-04-20
- Lead Sponsor
- University Health Network, Toronto
- Target Recruit Count
- 176
- Registration Number
- NCT00188630
- Locations
- 🇨🇦
Toronto General Hospital, UHN, Toronto, Ontario, Canada
COPD on Primary Care Treatment (COOPT)
- Conditions
- First Posted Date
- 2005-09-16
- Last Posted Date
- 2010-03-12
- Lead Sponsor
- Radboud University Medical Center
- Target Recruit Count
- 270
- Registration Number
- NCT00184977
- Locations
- 🇳🇱
Department of Family Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
🇳🇱Department of Family Medicine, University of Maastricht, Maastricht, Netherlands
Effectiveness of N-acetylcysteine in Treating Cocaine Dependent Individuals - 1
- First Posted Date
- 2005-08-29
- Last Posted Date
- 2017-01-12
- Lead Sponsor
- National Institute on Drug Abuse (NIDA)
- Target Recruit Count
- 17
- Registration Number
- NCT00136825
- Locations
- 🇺🇸
Medical University of South Carolina, Charleston, South Carolina, United States
Drug Development Updates
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