Acetylcysteine

Generic Name: Acetylcysteine

Brand Names: Acetadote

Drug Type: Small Molecule

Chemical Formula: C_₅H_₉NO_₃S

CAS Number: 616-91-1

Unique Ingredient Identifier: WYQ7N0BPYC

Background: Acetylcysteine is an antioxidant and glutathione inducer indicated for mucolytic therapy and the treatment of acetaminophen overdose. Acetylcysteine has also been studied for a wide variety of off-label indications with mixed results.

Acetylcysteine was granted FDA approval on 14 September 1963.

Indication: Acetylcysteine is indicated for mucolytic therapy and in the management of acetaminophen overdose.

Associated Conditions: Acetaminophen Overdose, Chronic Rhinitis, Corneal Diseases, Corneal ulceration, Crusting Rhinitis, Keratopathy, Rhinitis, Sinusitis, Vasomotor Rhinitis, Acute Rhinitis, Subacute Rhinitis

Associated Therapies: Airway secretion clearance therapy

Clinical Trials

Risk Stratification-directed NAC for Prevention of Poor Hematopoietic Reconstitution

Phase 3

Active, not recruiting

Conditions: Stem Cell Transplant Complications

Interventions: Drug: N-acetyl-L-cysteine

First Posted Date: 2019-05-30

Last Posted Date: 2021-09-14

Lead Sponsor: Peking University People's Hospital

Target Recruit Count: 130

Registration Number: NCT03967665

Locations: 🇨🇳
Peking University People's Hospital, Beijing, China

The Anti-oxidant Effects of N-Acetylcysteine in Chronic Obstructive Pulmonary Disease (COPD)

Phase 3

Conditions: Chronic Obstructive Pulmonary Disease

Interventions: Drug: N-acetylcysteine

First Posted Date: 2019-05-21

Last Posted Date: 2019-05-21

Lead Sponsor: Siriraj Hospital

Target Recruit Count: 30

Registration Number: NCT03956888

Locations: 🇹🇭
Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand

N-Acetylcysteine for Adolescent Alcohol Use Disorder

Phase 2

Completed

Conditions: Alcohol Use Disorder

Interventions: Drug: Placebo oral capsule
Drug: N-acetylcysteine

First Posted Date: 2018-10-16

Last Posted Date: 2024-02-28

Lead Sponsor: Medical University of South Carolina

Target Recruit Count: 120

Registration Number: NCT03707951

Locations: 🇺🇸
Medical University of South Carolina, Charleston, South Carolina, United States

Macrophage Markers, Soluble CD163 (sCD163) and Soluble CD206 (sCD206) in Paracetamol Overdose

Phase 1

Completed

Conditions: Drug-Induced Acute Liver Injury

Interventions: Drug: N-acetylcysteine

First Posted Date: 2018-09-20

Last Posted Date: 2018-09-24

Lead Sponsor: University of Aarhus

Target Recruit Count: 16

Registration Number: NCT03679442

Pilon Fracture With Intra-articular Injection of N-Acetylcysteine (Pilon NAC)

Phase 4

Recruiting

Conditions: Pilon Fracture

Interventions: Drug: Saline
Drug: N-acetylcysteine

First Posted Date: 2018-08-29

Last Posted Date: 2024-03-27

Lead Sponsor: University of Missouri-Columbia

Target Recruit Count: 30

Registration Number: NCT03652753

Locations: 🇺🇸
University of Missouri Health System, Columbia, Missouri, United States

Correction of Neonatal Glutathione by N-acetylcysteine in Pregnant Women at Risk of Premature Birth (GSH MAP)

Phase 2

Terminated

Conditions: Preterm Delivery

Interventions: Drug: Placebo
Drug: N-acetylcysteine

First Posted Date: 2018-07-23

Last Posted Date: 2022-12-19

Lead Sponsor: Nantes University Hospital

Target Recruit Count: 39

Registration Number: NCT03596125

Locations: 🇫🇷
Chu de Nantes, Nantes, France

Inpatient Clinical Trial of NAC

Phase 4

Terminated

Conditions: Asthma

Interventions: Drug: N-acetylcysteine

First Posted Date: 2018-07-10

Last Posted Date: 2021-10-26

Lead Sponsor: University of California, San Francisco

Target Recruit Count: 1

Registration Number: NCT03581084

Locations: 🇺🇸
University of California, San Francisco, San Francisco, California, United States

Clinical Trial of Antioxidant Therapy in Patients With Septic Shock

Phase 3

Conditions: Oxidative Stress
Septic Shock

Interventions: Drug: Melatonin 5 mg
Drug: Vitamin C 1 GM Oral Tablet
Drug: Vitamin E 400 UNT
Drug: N-acetylcysteine

First Posted Date: 2018-06-14

Last Posted Date: 2021-08-10

Lead Sponsor: American British Cowdray Medical Center

Target Recruit Count: 131

Registration Number: NCT03557229

Locations: 🇲🇽
Centro Médico ABC, Mexico City, Mexico

Evaluation of N-Acetylcysteine Efficacy to Reduce the Craving and to Prolong Abstinence Time of Coca Paste

Phase 2

Completed

Conditions: Cocaine-Related Disorders

Interventions: Drug: Placebo oral capsule
Drug: N-Acetylcysteine

First Posted Date: 2018-06-14

Last Posted Date: 2019-09-17

Lead Sponsor: University of Concepcion, Chile

Target Recruit Count: 140

Registration Number: NCT03556371

Locations: 🇨🇱
COSAM Lota, Lota, Concepción, Chile
🇨🇱
Therapeutic Community La Casa Chica, Talcahuano, Concepción, Chile
🇨🇱
Centro Terapéutico Anün, Coronel, Concepción, Chile

and more 2 locations

Sodium Benzoate and/or N-Acetylcysteine Added to TAU in Patients With Early Schizophrenia Spectrum Disorder.

Phase 2

Completed

Conditions: Schizophreniform Disorders
Schizophrenia
Schizoaffective Disorder

Interventions: Drug: Placebo
Drug: Sodium Benzoate
Drug: Sodium Benzoate Plus N-Acetylcysteine
Drug: N-Acetylcysteine

First Posted Date: 2018-04-27

Last Posted Date: 2022-04-27

Lead Sponsor: Pakistan Institute of Living and Learning

Target Recruit Count: 64

Registration Number: NCT03510741

Locations: 🇵🇰
Balochistan Institute of Behavioral Science, Quetta, Balochistan, Pakistan
🇵🇰
Institute of Psychiatry, Rawalpindi, Rawalpindi, Islamabad, Pakistan
🇵🇰
Civil Hospital Karachi, Karachi, Sindh, Pakistan

and more 2 locations

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