Megestrol acetate
- Generic Name
- Megestrol acetate
- Brand Names
- Megace
- Drug Type
- Small Molecule
- Chemical Formula
- C24H32O4
- CAS Number
- 595-33-5
- Unique Ingredient Identifier
- TJ2M0FR8ES
- Background
17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione. A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer.
- Indication
For the treatment of anorexia, cachexia, or an unexplained, significant weight loss in patients with a diagnosis of acquired immunodeficiency syndrome (AIDS). Also used for the palliative management of recurrent, inoperable, or metastatic breast cancer, endometrial cancer, and prostate cancer in Canada and some other countries.
- Associated Conditions
- Anorexia, Cachexia, Inoperable Carcinoma of Breast, Inoperable Endometrial Carcinoma, Metastatic Breast Carcinoma, Recurrent Breast Carcinoma, Recurrent Endometrial Carcinoma, Significant, Unexplained Weight Loss, Metastatic Endometrial carcinoma
- Associated Therapies
- Palliative Treatment
Megestrol Acetate Plus Rosuvastatin in Young Women With Early Endometrial Carcinoma
- Conditions
- Interventions
- First Posted Date
- 2020-07-29
- Last Posted Date
- 2024-01-29
- Lead Sponsor
- Fudan University
- Target Recruit Count
- 48
- Registration Number
- NCT04491643
- Locations
- 🇨🇳
Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China
IKanEat: a Randomized-controlled, Multi-center Trial of Megestrol for Chronic Oral Food Refusal in Children
- Conditions
- Interventions
- First Posted Date
- 2019-01-24
- Last Posted Date
- 2024-11-14
- Lead Sponsor
- University of Kansas Medical Center
- Target Recruit Count
- 71
- Registration Number
- NCT03815019
- Locations
- 🇺🇸
Rady Children's Hospital - San Diego, San Diego, California, United States
🇺🇸Arnold Palmer Hospital for Children, Orlando, Florida, United States
🇺🇸Riley Hospital for Children at IU Health, Indianapolis, Indiana, United States
Megestrol Acetate With or Without Pterostilbene in Treating Patients With Endometrial Cancer Undergoing Hysterectomy
- Conditions
- Interventions
- First Posted Date
- 2018-09-14
- Last Posted Date
- 2024-12-04
- Lead Sponsor
- City of Hope Medical Center
- Target Recruit Count
- 44
- Registration Number
- NCT03671811
- Locations
- 🇺🇸
City of Hope Medical Center, Duarte, California, United States
Megestrol Acetate Plus LNG-IUS in Young Women With Early Endometrial Cancer
- Conditions
- Interventions
- First Posted Date
- 2017-08-08
- Last Posted Date
- 2020-11-20
- Lead Sponsor
- Fudan University
- Target Recruit Count
- 64
- Registration Number
- NCT03241914
- Locations
- 🇨🇳
Obstetrics and Gynecology Hospital, Fudan University, Shanghai, Shanghai, China
Megestrol Acetate Plus LNG-IUS in Young Women With Endometrial Atypical Hyperplasia
- Conditions
- Interventions
- First Posted Date
- 2017-08-08
- Last Posted Date
- 2020-06-18
- Lead Sponsor
- Fudan University
- Target Recruit Count
- 180
- Registration Number
- NCT03241888
- Locations
- 🇨🇳
Obstetrics and Gynecology Hospital, Fudan University, Shanghai, Shanghai, China
The Safety and Effect Study of Acupuncture for Anorexia in Patients With Gastrointestinal Tract and Lung Cancers
- Conditions
- Interventions
- First Posted Date
- 2015-12-02
- Last Posted Date
- 2015-12-04
- Lead Sponsor
- Xinqiao Hospital of Chongqing
- Target Recruit Count
- 160
- Registration Number
- NCT02619266
- Locations
- 🇨🇳
Chongqing TCM Hospital, Jiangbei, Chongqing, China
🇨🇳XinQiao Hosiptal, Shapingba, Chongqing, China
🇨🇳Donghua Hosiptal, Shapingba, Chongqing, China
Phase II Study of Everolimus Beyond Progression
- Conditions
- Interventions
- First Posted Date
- 2014-10-21
- Last Posted Date
- 2022-04-05
- Lead Sponsor
- Emory University
- Target Recruit Count
- 3
- Registration Number
- NCT02269670
- Locations
- 🇺🇸
Emory University Hospital Midtown, Atlanta, Georgia, United States
🇺🇸Emory University/Winship Cancer Institute, Atlanta, Georgia, United States
🇺🇸Emory Saint Joseph's Hospital, Atlanta, Georgia, United States
Megestrol Acetate Plus Metformin to Megestrol Acetate in Patients With Endometrial Atypical Hyperplasia or Early Stage Endometrial Adenocarcinoma
- Conditions
- Interventions
- First Posted Date
- 2013-10-24
- Last Posted Date
- 2021-09-14
- Lead Sponsor
- Xiaojun Chen
- Target Recruit Count
- 150
- Registration Number
- NCT01968317
- Locations
- 🇨🇳
Obstetrics and Gynecology Hospital, Fudan University, Shanghai, Shanghai, China
🇨🇳Shanghai Changning Maternity & Infant Health Hospital, Shanghai, Shanghai, China
🇨🇳Shanghai Sixth People's Hospital, Shanghai, Shanghai, China
Megestrol Acetate or Levonorgestrel-Releasing Intrauterine System in Treating Patients With Atypical Endometrial Hyperplasia or Endometrial Cancer
- Conditions
- Endometrial AdenocarcinomaStage IA Endometrial CarcinomaRecurrent Endometrial CarcinomaStage IIIA Endometrial CarcinomaStage IIIC Endometrial CarcinomaStage IVA Endometrial CarcinomaStage IVB Endometrial CarcinomaAtypical Endometrial HyperplasiaStage IB Endometrial CarcinomaStage II Endometrial Carcinoma
- Interventions
- First Posted Date
- 2013-09-16
- Last Posted Date
- 2014-09-10
- Lead Sponsor
- University of Southern California
- Registration Number
- NCT01943058
Megestrol Acetate With or Without Mirtazapine in Treating Cancer Patients With Weight Loss or Loss of Appetite
- First Posted Date
- 2011-12-29
- Last Posted Date
- 2014-02-03
- Lead Sponsor
- Washington University School of Medicine
- Registration Number
- NCT01501396
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.