Overview
No overview information available.
Indication
用于接种6个月至10周岁的儿童及由非疫区进入疫区的成人可预防乙型脑炎。
Associated Conditions
- Japanese Encephalitis
Research Report
Japanese Encephalitis Virus Strain SA 14-14-2 Antigen (Formaldehyde Inactivated): A Comprehensive Review
1. Introduction to Japanese Encephalitis Virus Strain SA 14-14-2 Antigen (formaldehyde inactivated)
Overview of Japanese Encephalitis (JE) and Its Public Health Significance
Japanese Encephalitis (JE) is a severe mosquito-borne viral illness and a leading cause of viral encephalitis in Asia, particularly Southeast Asia.[1] The disease is caused by the Japanese Encephalitis Virus (JEV), a member of the Flaviviridae family.[3] JEV transmission follows a zoonotic cycle involving mosquitoes (primarily Culex species) as vectors, with water birds serving as natural reservoirs and pigs acting as significant amplifying hosts.[3] Humans are generally considered incidental or dead-end hosts because the level of viremia in infected individuals is typically insufficient to infect mosquitoes.[3]
While a large proportion of JEV infections are subclinical or result in mild, undifferentiated febrile illness, the development of clinical JE can have devastating consequences.[3] The incubation period in humans is estimated to be 5 to 15 days, often followed by the sudden onset of fever.[3] If the virus invades the central nervous system, it can manifest as meningitis, encephalitis, or myelitis.[3] Children are particularly vulnerable, often presenting with altered sensorium, seizures, and other severe neurological symptoms.[3] Approximately 1 in 250 JEV infections results in clinical disease.[3] Among those who develop encephalitis, the case-fatality rate can be as high as 30%, and around 30-50% of survivors experience significant long-term neurological or psychiatric sequelae, leading to lifelong disability.[3]
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
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2024/11/08 | Phase 1 | Recruiting | |||
2019/04/18 | Not Applicable | Completed |
FDA Drug Approvals
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No FDA approvals found for this drug. |
EMA Drug Approvals
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No EMA approvals found for this drug. |
HSA Drug Approvals
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No HSA approvals found for this drug. |
NMPA Drug Approvals
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No NMPA approvals found for this drug. |
PPB Drug Approvals
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No PPB approvals found for this drug. |
TGA Drug Approvals
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No TGA approvals found for this drug. |
Health Canada Drug Approvals
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No Health Canada approvals found for this drug. |
CIMA AEMPS Drug Approvals
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No CIMA AEMPS (Spain) approvals found for this drug. |
Philippines FDA Drug Approvals
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No Philippines FDA approvals found for this drug. |
Saudi SFDA Drug Approvals
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No Saudi SFDA approvals found for this drug. |
Malaysia NPRA Drug Approvals
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No Malaysia NPRA approvals found for this drug. |
UK EMC Drug Information
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No UK EMC drug information found for this drug. |
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