Etonogestrel
- Generic Name
- Etonogestrel
- Brand Names
- Eluryng, Enilloring, Implanon, Nexplanon, Nuvaring
- Drug Type
- Small Molecule
- Chemical Formula
- C22H28O2
- CAS Number
- 54048-10-1
- Unique Ingredient Identifier
- 304GTH6RNH
- Background
Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel. The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001.
- Indication
Etonogestrel is administered in subdermal implants as long-acting reversible contraception. It is known to be effective in postpartum insertion including breastfeeding women.
Etonogestrel is part of the long-acting contraceptive implants that prevent pregnancy. The implant's effect can remain for 5 years.
- Associated Therapies
- Contraception, Contraceptive implant therapy
Kuwa Free! - Live Free!
- Conditions
- HIV InfectionsContraceptionDrug-drug Interaction
- Interventions
- Drug: NNRTI, PI, or INSTI-containing 1st or 2nd line ART regimensDrug: Intramuscular depo-medroxyprogesterone acetate (IM DMPA)
- First Posted Date
- 2021-09-16
- Last Posted Date
- 2025-04-10
- Lead Sponsor
- University of Alabama at Birmingham
- Target Recruit Count
- 700
- Registration Number
- NCT05044962
- Locations
- 🇰🇪
Academic Model Providing Access to Healthcare (AMPATH) Moi Teaching And Referral Hospital (MTRH), Eldoret, Kenya
Impact of Contraceptives on Cervico-Vaginal Mucosa
- Conditions
- Contraceptive; Complications, IntrauterineMucosal Inflammation
- Interventions
- First Posted Date
- 2021-03-24
- Last Posted Date
- 2023-08-25
- Lead Sponsor
- Eastern Virginia Medical School
- Target Recruit Count
- 112
- Registration Number
- NCT04814927
- Locations
- 🇺🇸
Eastern Virginia Medical School, Norfolk, Virginia, United States
🇰🇪KEMRI, Thika, Central, Kenya
Evaluation of Pharmacokinetic Drug-drug Interactions Between Hormonal Contraceptives and Doravirine-containing ART Among Women Living With HIV in South Africa
- Conditions
- HIV InfectionsContraceptionDrug-drug Interaction
- Interventions
- Device: Non-hormonal intrauterine device (IUD)Drug: Intramuscular depo-medroxyprogesterone acetate (IM DMPA)Drug: Sub-cutaneous medroxyprogesterone acetate (SC MPA)
- First Posted Date
- 2020-12-17
- Last Posted Date
- 2025-04-08
- Lead Sponsor
- University of Alabama at Birmingham
- Target Recruit Count
- 110
- Registration Number
- NCT04669678
- Locations
- 🇿🇦
Wits Reproductive Health and HIV Institute, Research Centre Clinical Research Site, Johannesburg, South Africa
Shoulder Contraceptive Implant Study
- First Posted Date
- 2020-07-09
- Last Posted Date
- 2023-06-08
- Lead Sponsor
- University of Colorado, Denver
- Target Recruit Count
- 5
- Registration Number
- NCT04463693
- Locations
- 🇺🇸
University of Colorado Denver, Aurora, Colorado, United States
Nexplanon Use in Women Primarily Choosing a Combined Oral Contraceptive
- First Posted Date
- 2020-06-09
- Last Posted Date
- 2024-05-22
- Lead Sponsor
- University of California, Davis
- Target Recruit Count
- 120
- Registration Number
- NCT04423055
- Locations
- 🇺🇸
University of California, Davis, Sacramento, California, United States
🇺🇸University of Colorado, Denver, Colorado, United States
🇺🇸University of Pennsylvania, Philadelphia, Pennsylvania, United States
Breastfeeding Etonogestrel Implant Study
- First Posted Date
- 2019-06-07
- Last Posted Date
- 2024-10-26
- Lead Sponsor
- University of New Mexico
- Target Recruit Count
- 150
- Registration Number
- NCT03978598
- Locations
- 🇺🇸
University of Utah, Salt Lake City, Utah, United States
🇺🇸University of New Mexico, Albuquerque, New Mexico, United States
Contraceptive Hormones, Immunity, and Microbiome Evaluation
- Conditions
- Hormonal Contraception
- Interventions
- Drug: Depot medroxyprogesterone acetate (DMPA)
- First Posted Date
- 2018-09-06
- Last Posted Date
- 2024-10-29
- Lead Sponsor
- Emory University
- Target Recruit Count
- 155
- Registration Number
- NCT03660046
- Locations
- 🇺🇸
Grady Health System, Atlanta, Georgia, United States
🇺🇸The Emory Clinic, Bldg A., 2nd Floor, 1365 Clifton Road, NE, Atlanta, Georgia, United States
🇺🇸Atlanta Women's Center, Atlanta, Georgia, United States
Antepartum Etonogestrel Contraceptive Implant Insertion at Term
- First Posted Date
- 2018-09-04
- Last Posted Date
- 2019-04-17
- Lead Sponsor
- University of Colorado, Denver
- Registration Number
- NCT03656289
- Locations
- 🇺🇸
University of Colorado Denver, Aurora, Colorado, United States
Darunavir and Rilpivirine Interactions With Etonogestrel Contraceptive Implant
- Conditions
- HIVContraception
- Interventions
- First Posted Date
- 2018-07-17
- Last Posted Date
- 2019-03-28
- Lead Sponsor
- Makerere University
- Target Recruit Count
- 60
- Registration Number
- NCT03589040
- Locations
- 🇺🇬
Infectious Diseases Institue, Kampala, Uganda
Immediate Versus Delayed Insertion of Implanon in Postpartum Adolescents
- First Posted Date
- 2018-07-13
- Last Posted Date
- 2018-10-04
- Lead Sponsor
- Medical University of South Carolina
- Target Recruit Count
- 81
- Registration Number
- NCT03585504
- Locations
- 🇺🇸
Medical University of South Carolina, Charleston, South Carolina, United States
Drug Development Updates
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