Cholic Acid
- Generic Name
- Cholic Acid
- Brand Names
- Cholbam, Orphacol
- Drug Type
- Small Molecule
- Chemical Formula
- C24H40O5
- CAS Number
- 81-25-4
- Unique Ingredient Identifier
- G1JO7801AE
- Background
A major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. [PubChem]
Cholic acid, formulated as Cholbam capsules, is approved by the United States Food and Drug Administration as a treatment for children and adults with bile acid synthesis disorders due to single enzyme defects, and for peroxisomal disorders (such as Zellweger syndrome).
- Indication
Oral cholic acid is indicated for: treatment of bile acid synthesis disorders due to single enzyme defects; and as adjunctive treatment of peroxisomal disorders including Zellweger spectrum disorders in patients who exhibit manifestations of liver disease, steatorrhea or complications from decreased fat soluble vitamin absorption.
- Associated Conditions
- Inborn Errors of Bile Acid Synthesis, Zellweger Spectrum Disorder, Peroxisomal disorders (PDs)
- Associated Therapies
- -
Volixibat Granted Breakthrough Therapy Designation for Cholestatic Pruritus in Primary Biliary Cholangitis
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