Prednisone

Generic Name: Prednisone

Brand Names: Deltasone, Rayos, Winpred

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₂₆O_₅

CAS Number: 53-03-2

Unique Ingredient Identifier: VB0R961HZT

Background: A synthetic anti-inflammatory glucocorticoid derived from cortisone. It is biologically inert and converted to prednisolone in the liver.

Prednisone was granted FDA approval on 21 February 1955.

Indication: Prednisone is indicated as an anti-inflammatory or immunosuppressive drug for allergic, dermatologic, gastrointestinal, hematologic, ophthalmologic, nervous system, renal, respiratory, rheumatologic, infectious, endocrine, or neoplastic conditions as well as in organ transplant.

Associated Conditions: Acne Vulgaris, Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Acute Gouty Arthritis, Acute Leukemia, Aggressive Lymphoma, Allergic Bronchopulmonary Aspergillosis, Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergic corneal marginal ulcers, Alveolitis, Extrinsic Allergic, Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Autoimmune Hepatitis, Bell's Palsy, Berylliosis, Bullous dermatitis herpetiformis, Chorioretinitis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Contact Dermatitis, Disseminated tuberculosis, Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Erythroblastopenia, Giant Cell Arteritis (GCA), Hypercalcemia of Malignancy, Idiopathic Pulmonary Fibrosis (IPF), Immune Thrombocytopenia (ITP), Iridocyclitis, Iritis, Keratitis, Leukemias, Loeffler's syndrome, Lymphoma, Meningitis caused by Mycobacterium Tuberculosis, Metastatic Castration-Resistant Prostate Cancer (mCRPC), Mycosis Fungoides (MF), Ocular Inflammation, Ophthalmia, Sympathetic, Optic Neuritis, Pain caused by Herpes zoster, Pemphigus, Pericarditis, Pneumocystis Jirovecii Pneumonia, Polymyalgia Rheumatica (PMR), Polymyositis, Posterior Uveitis, Primary adrenocortical insufficiency, Psoriatic Arthritis, Pure Red Cell Aplasia, Regional Enteritis, Relapsing Polychondritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Secondary adrenocortical insufficiency, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Sjogren's Syndrome (SS), Solid Organ Transplant Rejection, Stevens-Johnson Syndrome, Systemic Lupus Erythematosus, Takayasu Arteritis, Thyroid Eye Disease, Thyroiditis, Thyrotoxicosis, Trichinosis, Ulcerative Colitis, Uveitis, Vasculitis, Acquired immune hemolytic anemia, Acute Bursitis, Acute Crohn's Disease (CD), Acute Multiple sclerosis exacerbation, Acute rheumatic carditis, Anterior eye segment inflammation, Exfoliative erythroderma, Fulminating Tuberculosis, Idiopathic Bronchiolitis obliterans with organizing pneumonia, Idiopathic eosinophilic pneumonias, Non-suppurative Thyroiditis, Severe Psoriasis, Subacute Bursitis, Symptomatic Sarcoidosis, Synovitis of osteoarthritis, Systemic Dermatomyositis, Varicella-zoster virus acute retinal necrosis

Associated Therapies: Palliative Treatment

Clinical Trials

A Study of Polatuzumab Vedotin, Rituximab and Dose Attenuated CHP in Older Patients with DLBCL

Phase 2

Recruiting

Conditions: Lymphoma, B-Cell
DLBCL

Interventions: Drug: Polatuzumab vedotin
Drug: Rituximab
Drug: Cyclophosphamide
Drug: Doxorubicin
Drug: Prednisone

First Posted Date: 2020-10-20

Last Posted Date: 2024-11-05

Lead Sponsor: University of Rochester

Target Recruit Count: 39

Registration Number: NCT04594798

Locations: 🇺🇸
University of Rochester, Rochester, New York, United States

A Study of Comparative Formulations of Niraparib and Abiraterone Acetate (AA) in Men With Prostate Cancer

Phase 1

Active, not recruiting

Conditions: Prostatic Neoplasms

Interventions: Drug: Niraparib
Drug: Abiraterone Acetate (AA)
Drug: Prednisone

First Posted Date: 2020-10-08

Last Posted Date: 2024-12-06

Lead Sponsor: Janssen Research & Development, LLC

Target Recruit Count: 136

Registration Number: NCT04577833

Locations: 🇳🇱
Erasmus MC, Rotterdam, Netherlands
🇵🇱
Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy, Warszawa, Poland
🇫🇷
HIA Begin, Saint Mande, France

and more 12 locations

Treatment of Pregnancy RA

Not Applicable

Conditions: Rheumatoid Arthritis
Pregnancy Related

Interventions: Drug: Certolizumab Pegol 200 MG/ML [Cimzia]
Drug: Hydroxychloroquine
Drug: Prednisone

First Posted Date: 2020-09-30

Last Posted Date: 2020-10-01

Lead Sponsor: RenJi Hospital

Target Recruit Count: 100

Registration Number: NCT04569890

Locations: 🇨🇳
Renji Hospital, Shanghai, Shanghai, China

A Study of Brentuximab Vedotin and CHP in Frontline Treatment of PTCL With Less Than 10% CD30 Expression

Phase 2

Active, not recruiting

Conditions: Peripheral T-cell Lymphoma

Interventions: Drug: brentuximab vedotin
Drug: cyclophosphamide
Drug: doxorubicin
Drug: prednisone

First Posted Date: 2020-09-29

Last Posted Date: 2024-10-15

Lead Sponsor: Seagen Inc.

Target Recruit Count: 82

Registration Number: NCT04569032

Locations: 🇺🇸
Stanford Cancer Center / Blood and Marrow Transplant Program, Stanford, California, United States
🇺🇸
Rocky Mountain Cancer Centers - Aurora, Aurora, Colorado, United States
🇺🇸
Johns Hopkins Medical Center, Washington, District of Columbia, United States

and more 48 locations

Low Dose Prednisone Therapy in Women With Recurrent Pregnancy Loss

Phase 2

Conditions: Recurrent Pregnancy Loss(RPL)
Recurrent Miscarriage

Interventions: Drug: Prednisone
Drug: Progesterone
Dietary Supplement: vit D
Dietary Supplement: Iron Supplement
Dietary Supplement: Folic Acid

First Posted Date: 2020-09-22

Last Posted Date: 2020-09-22

Lead Sponsor: Soroka University Medical Center

Target Recruit Count: 242

Registration Number: NCT04558268

Locations: 🇮🇱
Soroka Medical Center, Be'er Sheva, Israel

PLX2853 in Combination With Abiraterone Acetate and Prednisone and in Combination With Olaparib in Subjects With Metastatic Castration-Resistant Prostate Cancer (mCRPC)

Phase 1

Terminated

Conditions: Metastatic Castration-resistant Prostate Cancer

Interventions: Drug: PLX2853
Drug: Abiraterone acetate
Drug: Olaparib
Drug: Prednisone

First Posted Date: 2020-09-21

Last Posted Date: 2022-10-05

Lead Sponsor: Opna Bio LLC

Target Recruit Count: 19

Registration Number: NCT04556617

Locations: 🇺🇸
University of Chicago, Chicago, Illinois, United States
🇬🇧
Sarah Cannon Research Institute, London, United Kingdom
🇺🇸
Carolina Urologic Research Center, Myrtle Beach, South Carolina, United States

and more 5 locations