Prednisone

Generic Name: Prednisone

Brand Names: Deltasone, Rayos, Winpred

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₂₆O_₅

CAS Number: 53-03-2

Unique Ingredient Identifier: VB0R961HZT

Background: A synthetic anti-inflammatory glucocorticoid derived from cortisone. It is biologically inert and converted to prednisolone in the liver.

Prednisone was granted FDA approval on 21 February 1955.

Indication: Prednisone is indicated as an anti-inflammatory or immunosuppressive drug for allergic, dermatologic, gastrointestinal, hematologic, ophthalmologic, nervous system, renal, respiratory, rheumatologic, infectious, endocrine, or neoplastic conditions as well as in organ transplant.

Associated Conditions: Acne Vulgaris, Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Acute Gouty Arthritis, Acute Leukemia, Aggressive Lymphoma, Allergic Bronchopulmonary Aspergillosis, Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergic corneal marginal ulcers, Alveolitis, Extrinsic Allergic, Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Autoimmune Hepatitis, Bell's Palsy, Berylliosis, Bullous dermatitis herpetiformis, Chorioretinitis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Contact Dermatitis, Disseminated tuberculosis, Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Erythroblastopenia, Giant Cell Arteritis (GCA), Hypercalcemia of Malignancy, Idiopathic Pulmonary Fibrosis (IPF), Immune Thrombocytopenia (ITP), Iridocyclitis, Iritis, Keratitis, Leukemias, Loeffler's syndrome, Lymphoma, Meningitis caused by Mycobacterium Tuberculosis, Metastatic Castration-Resistant Prostate Cancer (mCRPC), Mycosis Fungoides (MF), Ocular Inflammation, Ophthalmia, Sympathetic, Optic Neuritis, Pain caused by Herpes zoster, Pemphigus, Pericarditis, Pneumocystis Jirovecii Pneumonia, Polymyalgia Rheumatica (PMR), Polymyositis, Posterior Uveitis, Primary adrenocortical insufficiency, Psoriatic Arthritis, Pure Red Cell Aplasia, Regional Enteritis, Relapsing Polychondritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Secondary adrenocortical insufficiency, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Sjogren's Syndrome (SS), Solid Organ Transplant Rejection, Stevens-Johnson Syndrome, Systemic Lupus Erythematosus, Takayasu Arteritis, Thyroid Eye Disease, Thyroiditis, Thyrotoxicosis, Trichinosis, Ulcerative Colitis, Uveitis, Vasculitis, Acquired immune hemolytic anemia, Acute Bursitis, Acute Crohn's Disease (CD), Acute Multiple sclerosis exacerbation, Acute rheumatic carditis, Anterior eye segment inflammation, Exfoliative erythroderma, Fulminating Tuberculosis, Idiopathic Bronchiolitis obliterans with organizing pneumonia, Idiopathic eosinophilic pneumonias, Non-suppurative Thyroiditis, Severe Psoriasis, Subacute Bursitis, Symptomatic Sarcoidosis, Synovitis of osteoarthritis, Systemic Dermatomyositis, Varicella-zoster virus acute retinal necrosis

Associated Therapies: Palliative Treatment

Clinical Trials

Clinical Trial of Chidamide Combined With CHOP in Peripheral T-cell Lymphoma Patients

Phase 1

Completed

Conditions: Peripheral T-cell Lymphoma

Interventions: Drug: Chidamide
Drug: cyclophosphamide
Drug: adriacin
Drug: vincristine
Drug: prednisone

First Posted Date: 2016-06-22

Last Posted Date: 2019-07-24

Lead Sponsor: Chipscreen Biosciences, Ltd.

Target Recruit Count: 30

Registration Number: NCT02809573

Locations: 🇨🇳
Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, Beijing, China

Abiraterone Acetate, Niclosamide, and Prednisone in Treating Patients With Hormone-Resistant Prostate Cancer

Phase 2

Active, not recruiting

Conditions: Recurrent Prostate Carcinoma
Stage IV Prostate Cancer
Metastatic Prostate Carcinoma

Interventions: Drug: Abiraterone Acetate
Drug: Niclosamide
Drug: Prednisone

First Posted Date: 2016-06-21

Last Posted Date: 2024-12-18

Lead Sponsor: Mamta Parikh

Target Recruit Count: 37

Registration Number: NCT02807805

Locations: 🇺🇸
University of California Davis Comprehensive Cancer Center, Sacramento, California, United States

A Study to Evaluate Steroid-free Treatment for Standard-Risk aGVHD (BMT CTN 1501)

Phase 2

Completed

Conditions: Acute GVHD

Interventions: Drug: Prednisone
Drug: Sirolimus

First Posted Date: 2016-06-21

Last Posted Date: 2021-11-01

Lead Sponsor: Medical College of Wisconsin

Target Recruit Count: 127

Registration Number: NCT02806947

Locations: 🇺🇸
Emory University, Atlanta, Georgia, United States
🇺🇸
Children's Hospital Los Angeles, Los Angeles, California, United States
🇺🇸
Blood & Marrow Transplant Program at Northside Hospital, Atlanta, Georgia, United States

and more 18 locations

Treatment for Classical Hodgkin Lymphoma in Children and Adolescents

Not Applicable

Recruiting

Conditions: Classical Hodgkins Lymphoma in Children and Adolescents.

Interventions: Drug: Vincristine
Drug: Prednisone
Drug: Etoposide
Drug: Dacarbazine
Drug: Cyclophosphamide
Drug: Doxorubicin

First Posted Date: 2016-06-13

Last Posted Date: 2016-06-14

Lead Sponsor: GALIA AVRAHAMI

Target Recruit Count: 2200

Registration Number: NCT02797717

Locations: 🇮🇱
Schneider children's medical center, Petach-Tikva, Israel

Neoadjuvant Androgen Deprivation Therapy Plus Abiraterone With or Without Apalutamide for High-Risk Prostate Cancer

Phase 2

Completed

Conditions: Prostate Cancer

Interventions: Drug: Goserelin
Drug: Prednisone
Drug: Abiraterone
Drug: Apalutamide

First Posted Date: 2016-06-03

Last Posted Date: 2022-09-15

Lead Sponsor: Instituto do Cancer do Estado de São Paulo

Target Recruit Count: 64

Registration Number: NCT02789878

Locations: 🇧🇷
Instituto do Cancer do Estado de Sao Paulo, Sao Paulo, SP, Brazil

Effect of Corticosteroids on Inflammation at the Edge of Acute Multiple Sclerosis Plaques

Phase 2

Recruiting

Conditions: Multiple Sclerosis

Interventions: Drug: Methylprednisolone
Drug: Prednisone

First Posted Date: 2016-05-27

Last Posted Date: 2024-11-11

Lead Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Target Recruit Count: 30

Registration Number: NCT02784210

Locations: 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States

Steroids in Children Hospitalized With Asthma

Phase 4

Terminated

Conditions: Asthma
Status Asthmaticus
Wheezes

Interventions: Drug: Dexamethasone
Drug: Prednisone

First Posted Date: 2016-05-23

Last Posted Date: 2019-06-21

Lead Sponsor: University of Florida

Target Recruit Count: 6

Registration Number: NCT02780479

Locations: 🇺🇸
Wolfson Children Hospital, Jacksonville, Florida, United States

Reducing Dexamethasone Around Docetaxel Infusion

Phase 1

Conditions: Breast Cancer
Prostate Cancer

Interventions: Drug: Dexamethasone
Drug: Prednisone

First Posted Date: 2016-05-18

Last Posted Date: 2021-04-02

Lead Sponsor: Leiden University Medical Center

Target Recruit Count: 46

Registration Number: NCT02776436

Locations: 🇳🇱
Haga hospital, Den Haag, Netherlands
🇳🇱
Reinier de Graaf hospital, Delft, Netherlands
🇳🇱
Leiden university medical center, Leiden, Netherlands