Prednisone

Generic Name: Prednisone

Brand Names: Deltasone, Rayos, Winpred

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₂₆O_₅

CAS Number: 53-03-2

Unique Ingredient Identifier: VB0R961HZT

Background: A synthetic anti-inflammatory glucocorticoid derived from cortisone. It is biologically inert and converted to prednisolone in the liver.

Prednisone was granted FDA approval on 21 February 1955.

Indication: Prednisone is indicated as an anti-inflammatory or immunosuppressive drug for allergic, dermatologic, gastrointestinal, hematologic, ophthalmologic, nervous system, renal, respiratory, rheumatologic, infectious, endocrine, or neoplastic conditions as well as in organ transplant.

Associated Conditions: Acne Vulgaris, Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Acute Gouty Arthritis, Acute Leukemia, Aggressive Lymphoma, Allergic Bronchopulmonary Aspergillosis, Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergic corneal marginal ulcers, Alveolitis, Extrinsic Allergic, Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Autoimmune Hepatitis, Bell's Palsy, Berylliosis, Bullous dermatitis herpetiformis, Chorioretinitis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Contact Dermatitis, Disseminated tuberculosis, Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Erythroblastopenia, Giant Cell Arteritis (GCA), Hypercalcemia of Malignancy, Idiopathic Pulmonary Fibrosis (IPF), Immune Thrombocytopenia (ITP), Iridocyclitis, Iritis, Keratitis, Leukemias, Loeffler's syndrome, Lymphoma, Meningitis caused by Mycobacterium Tuberculosis, Metastatic Castration-Resistant Prostate Cancer (mCRPC), Mycosis Fungoides (MF), Ocular Inflammation, Ophthalmia, Sympathetic, Optic Neuritis, Pain caused by Herpes zoster, Pemphigus, Pericarditis, Pneumocystis Jirovecii Pneumonia, Polymyalgia Rheumatica (PMR), Polymyositis, Posterior Uveitis, Primary adrenocortical insufficiency, Psoriatic Arthritis, Pure Red Cell Aplasia, Regional Enteritis, Relapsing Polychondritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Secondary adrenocortical insufficiency, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Sjogren's Syndrome (SS), Solid Organ Transplant Rejection, Stevens-Johnson Syndrome, Systemic Lupus Erythematosus, Takayasu Arteritis, Thyroid Eye Disease, Thyroiditis, Thyrotoxicosis, Trichinosis, Ulcerative Colitis, Uveitis, Vasculitis, Acquired immune hemolytic anemia, Acute Bursitis, Acute Crohn's Disease (CD), Acute Multiple sclerosis exacerbation, Acute rheumatic carditis, Anterior eye segment inflammation, Exfoliative erythroderma, Fulminating Tuberculosis, Idiopathic Bronchiolitis obliterans with organizing pneumonia, Idiopathic eosinophilic pneumonias, Non-suppurative Thyroiditis, Severe Psoriasis, Subacute Bursitis, Symptomatic Sarcoidosis, Synovitis of osteoarthritis, Systemic Dermatomyositis, Varicella-zoster virus acute retinal necrosis

Associated Therapies: Palliative Treatment

Clinical Trials

Efficacy and Safety Study of Abatacept to Treat Lupus Nephritis

Phase 3

Terminated

Conditions: Lupus Nephritis

Interventions: Biological: BMS-188667
Drug: Mycophenolate mofetil
Biological: Placebo matching with BMS-188667
Drug: Prednisone

First Posted Date: 2012-10-26

Last Posted Date: 2021-02-26

Lead Sponsor: Bristol-Myers Squibb

Target Recruit Count: 695

Registration Number: NCT01714817

Locations: 🇨🇴
Riesgo De Fractura S.A. Cayre Ips, Bogota, Cundinamarca, Colombia
🇨🇴
Circaribe S.A.S, Barranquilla, Colombia
🇨🇴
Servimed E.U, Bucaramanga, Santander, Colombia

and more 39 locations

A Study of Abiraterone Acetate Plus Low-Dose Prednisone Plus Androgen Deprivation Therapy (ADT) Versus ADT Alone in Newly Diagnosed Participants With High-Risk, Metastatic Hormone-Naive Prostate Cancer (mHNPC)

Phase 3

Completed

Conditions: Prostate Neoplasms

Interventions: Other: Androgen deprivation therapy (ADT)
Drug: Abiraterone acetate
Drug: Abiraterone acetate Placebo
Drug: Prednisone
Drug: Prednisone Placebo

First Posted Date: 2012-10-26

Last Posted Date: 2023-03-13

Lead Sponsor: Janssen Research & Development, LLC

Target Recruit Count: 1209

Registration Number: NCT01715285

A Study to Evaluate the Effect of Multiple Doses of Isavuconazole on the Pharmacokinetics of a Single Dose of Prednisone in Healthy Adult Subjects

Phase 1

Completed

Conditions: Healthy Subjects
Pharmacokinetics of Isavuconazole
Pharmacokinetics of Prednisolone

Interventions: Drug: Isavuconazole
Drug: Prednisone

First Posted Date: 2012-10-22

Last Posted Date: 2012-10-22

Lead Sponsor: Astellas Pharma Global Development, Inc.

Target Recruit Count: 21

Registration Number: NCT01711827

Locations: 🇺🇸
Parexel International, LLC, Glendale, California, United States

A Study of Abiraterone Acetate Plus Prednisone in Patients With Metastatic Castration-Resistant Prostate Cancer Who Have Failed Docetaxel-Based Chemotherapy

Phase 3

Completed

Conditions: Prostate Neoplasms

Interventions: Drug: Placebo
Drug: Abiraterone acetate
Drug: Prednisone

First Posted Date: 2012-09-27

Last Posted Date: 2019-07-18

Lead Sponsor: Janssen Research & Development, LLC

Target Recruit Count: 214

Registration Number: NCT01695135

A Study of LY3039478 in Participants With Advanced Cancer

Phase 1

Completed

Conditions: Neoplasms
Lymphoma
Neoplasm Metastasis

Interventions: Drug: LY3039478
Drug: Prednisone

First Posted Date: 2012-09-27

Last Posted Date: 2018-08-07

Lead Sponsor: Eli Lilly and Company

Target Recruit Count: 237

Registration Number: NCT01695005

Locations: 🇺🇸
University of Miami School of Medicine, Miami, Florida, United States
🇺🇸
Columbia University Medical Center, New York, New York, United States
🇬🇧
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., London, United Kingdom

and more 3 locations

Post-marketing Surveillance Study on the Safety and Effectiveness of Abiraterone Acetate Among Adult Filipino Male Patients With Advanced Metastatic Castration Resistant Prostate Cancer

Withdrawn

Conditions: Prostate Neoplasms

Interventions: Drug: Abiraterone acetate
Drug: Prednisone

First Posted Date: 2012-09-25

Last Posted Date: 2015-12-02

Lead Sponsor: Janssen Pharmaceutica

Registration Number: NCT01692483

A Study of HSP90 Inhibitor AT13387 Alone or in Combination With Abiraterone Acetate

Phase 1

Completed

Conditions: Prostate Cancer

Interventions: Drug: AT13387
Drug: abiraterone acetate
Drug: Prednisone

First Posted Date: 2012-09-14

Last Posted Date: 2024-08-02

Lead Sponsor: Astex Pharmaceuticals, Inc.

Target Recruit Count: 49

Registration Number: NCT01685268

Locations: 🇺🇸
The West Clinic, Memphis, Tennessee, United States
🇺🇸
Clinical Research Alliance, Inc., Lake Success, New York, United States
🇺🇸
Columbia University Medical Center, New York, New York, United States

and more 29 locations