Prednisone

Generic Name: Prednisone

Brand Names: Deltasone, Rayos, Winpred

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₂₆O_₅

CAS Number: 53-03-2

Unique Ingredient Identifier: VB0R961HZT

Background: A synthetic anti-inflammatory glucocorticoid derived from cortisone. It is biologically inert and converted to prednisolone in the liver.

Prednisone was granted FDA approval on 21 February 1955.

Indication: Prednisone is indicated as an anti-inflammatory or immunosuppressive drug for allergic, dermatologic, gastrointestinal, hematologic, ophthalmologic, nervous system, renal, respiratory, rheumatologic, infectious, endocrine, or neoplastic conditions as well as in organ transplant.

Associated Conditions: Acne Vulgaris, Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Acute Gouty Arthritis, Acute Leukemia, Aggressive Lymphoma, Allergic Bronchopulmonary Aspergillosis, Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergic corneal marginal ulcers, Alveolitis, Extrinsic Allergic, Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Autoimmune Hepatitis, Bell's Palsy, Berylliosis, Bullous dermatitis herpetiformis, Chorioretinitis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Contact Dermatitis, Disseminated tuberculosis, Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Erythroblastopenia, Giant Cell Arteritis (GCA), Hypercalcemia of Malignancy, Idiopathic Pulmonary Fibrosis (IPF), Immune Thrombocytopenia (ITP), Iridocyclitis, Iritis, Keratitis, Leukemias, Loeffler's syndrome, Lymphoma, Meningitis caused by Mycobacterium Tuberculosis, Metastatic Castration-Resistant Prostate Cancer (mCRPC), Mycosis Fungoides (MF), Ocular Inflammation, Ophthalmia, Sympathetic, Optic Neuritis, Pain caused by Herpes zoster, Pemphigus, Pericarditis, Pneumocystis Jirovecii Pneumonia, Polymyalgia Rheumatica (PMR), Polymyositis, Posterior Uveitis, Primary adrenocortical insufficiency, Psoriatic Arthritis, Pure Red Cell Aplasia, Regional Enteritis, Relapsing Polychondritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Secondary adrenocortical insufficiency, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Sjogren's Syndrome (SS), Solid Organ Transplant Rejection, Stevens-Johnson Syndrome, Systemic Lupus Erythematosus, Takayasu Arteritis, Thyroid Eye Disease, Thyroiditis, Thyrotoxicosis, Trichinosis, Ulcerative Colitis, Uveitis, Vasculitis, Acquired immune hemolytic anemia, Acute Bursitis, Acute Crohn's Disease (CD), Acute Multiple sclerosis exacerbation, Acute rheumatic carditis, Anterior eye segment inflammation, Exfoliative erythroderma, Fulminating Tuberculosis, Idiopathic Bronchiolitis obliterans with organizing pneumonia, Idiopathic eosinophilic pneumonias, Non-suppurative Thyroiditis, Severe Psoriasis, Subacute Bursitis, Symptomatic Sarcoidosis, Synovitis of osteoarthritis, Systemic Dermatomyositis, Varicella-zoster virus acute retinal necrosis

Associated Therapies: Palliative Treatment

Clinical Trials

Prednisone or Dexamethasone in Newly Diagnosed, Previously Untreated Primary Immune Thrombocytopenic Purpura

Phase 3

Completed

Conditions: Nonneoplastic Condition

Interventions: Drug: dexamethasone
Drug: prednisone
Procedure: quality-of-life assessment

First Posted Date: 2008-04-14

Last Posted Date: 2017-02-20

Lead Sponsor: Gruppo Italiano Malattie EMatologiche dell'Adulto

Target Recruit Count: 150

Registration Number: NCT00657410

Locations: 🇮🇹
S.O.C. di Ematologia - Azienda Ospedaliera - SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy
🇮🇹
USL 8 - Ospedale S.Donato, Arezzo, Italy
🇮🇹
UO Ematologia con trapianto- AOU Policlinico Consorziale di Bari, Bari, Italy

and more 39 locations

Aprepitant's Effect on Drug Metabolism in Multi-Day Combination (CHOP/R-CHOP) Chemotherapy Regimen in Lymphoma Patients

Not Applicable

Completed

Conditions: Lymphoma

Interventions: Drug: Cyclophosphamide
Drug: Aprepitant
Drug: Vincristine
Drug: Doxorubicin
Drug: Prednisone
Drug: Rituximab
Drug: Ondansetron

First Posted Date: 2008-04-03

Last Posted Date: 2013-07-02

Lead Sponsor: M.D. Anderson Cancer Center

Target Recruit Count: 23

Registration Number: NCT00651755

Locations: 🇺🇸
UT MD Anderson Cancer Center, Houston, Texas, United States

Combined Treatment of Methotrexate + Glucocorticoids Versus Glucocorticoids Alone in Patients With PM and DM

Phase 3

Completed

Conditions: Dermatomyositis
Polymyositis

Interventions: Drug: Prednisone
Drug: Methotrexate

First Posted Date: 2008-04-02

Last Posted Date: 2016-05-12

Lead Sponsor: Institute of Rheumatology, Prague

Target Recruit Count: 31

Registration Number: NCT00651040

Locations: 🇨🇿
Revmatologicky ustav, Prague, Czech Republic

A Study of an Experimental Chemotherapy Combination to Treat Hormone Refractory Prostate Cancer

Phase 2

Completed

Conditions: Prostate Cancer

Interventions: Drug: docetaxel
Drug: LY2181308 sodium
Drug: Prednisone

First Posted Date: 2008-03-24

Last Posted Date: 2019-04-03

Lead Sponsor: Eli Lilly and Company

Target Recruit Count: 154

Registration Number: NCT00642018

Locations: 🇪🇸
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Pamplona, Spain

Study Evaluating 2 Dosing Regimens Of TRU-015 In Rheumatoid Arthritis

Phase 2

Terminated

Conditions: Arthritis, Rheumatoid

Interventions: Drug: TRU-015
Drug: Methylprednisolone
Drug: Prednisone

First Posted Date: 2008-03-13

Last Posted Date: 2013-03-11

Lead Sponsor: Pfizer

Target Recruit Count: 222

Registration Number: NCT00634933

Locations: 🇷🇸
Pfizer Investigational Site, Niska Banja, Serbia

Satraplatin and Prednisone to Treat Prostate Cancer

Phase 2

Completed

Conditions: Prostate Cancer
Genetic Polymorphism

Interventions: Drug: Satraplatin
Drug: prednisone

First Posted Date: 2008-03-13

Last Posted Date: 2018-10-02

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 24

Registration Number: NCT00634647

Locations: 🇺🇸
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States
🇺🇸
Associates in Oncology and Hematology, Rockville, Maryland, United States