Overview
Deoxycholic acid is a a bile acid which emulsifies and solubilizes dietary fats in the intestine, and when injected subcutaneously, it disrupts cell membranes in adipocytes and destroys fat cells in that tissue. In April 2015, deoxycholic acid was approved by the FDA for the treatment submental fat to improve aesthetic appearance and reduce facial fullness or convexity. It is marketed under the brand name Kybella by Kythera Biopharma and is the first pharmacological agent available for submental fat reduction, allowing for a safer and less invasive alternative than surgical procedures.
Indication
For improvement in appearance of moderate to severe fullness associated with submental fat in adults.
Associated Conditions
No associated conditions information available.
Clinical Trials
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Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2019/08/13 | Early Phase 1 | Completed | |||
2018/10/19 | Phase 4 | Completed | |||
2018/10/01 | N/A | Terminated | |||
2018/09/24 | N/A | Completed | |||
2018/04/27 | Phase 4 | Completed | Zeltiq Aesthetics | ||
2018/02/07 | Phase 4 | Completed | |||
2017/12/04 | Phase 4 | Completed | Goldman, Butterwick, Fitzpatrick and Groff | ||
2017/08/07 | Phase 4 | Completed | Goldman, Butterwick, Fitzpatrick and Groff | ||
2015/05/08 | N/A | Completed | Kythera Biopharmaceuticals | ||
2014/01/14 | Phase 3 | Completed | Kythera Biopharmaceuticals |
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