Darbepoetin alfa
- Generic Name
- Darbepoetin alfa
- Brand Names
- Aranesp
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 209810-58-2
- Unique Ingredient Identifier
- 15UQ94PT4P
- Background
Human erythropoietin with 2 aa substitutions to enhance glycosylation (5 N-linked chains), 165 residues (MW=37 kD). Produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology.
- Indication
For the treatment of anemia (from renal transplants or certain HIV treatment)
- Associated Conditions
- Anemia
- Associated Therapies
- -
COMFORT Study: A Crossover Study of NeoRecormon (Epoetin Beta) and Darbepoetin Alfa in Patients With Renal Anemia.
- First Posted Date
- 2006-09-18
- Last Posted Date
- 2016-11-02
- Lead Sponsor
- Hoffmann-La Roche
- Target Recruit Count
- 48
- Registration Number
- NCT00377481
STAAR-2 Clinical Study
Phase 4
Completed
- Conditions
- Interventions
- First Posted Date
- 2006-08-29
- Last Posted Date
- 2010-03-05
- Lead Sponsor
- Amgen
- Target Recruit Count
- 618
- Registration Number
- NCT00368901
STAAR-3 Clinical Study
Phase 4
Completed
- Conditions
- Interventions
- First Posted Date
- 2006-08-29
- Last Posted Date
- 2010-02-19
- Lead Sponsor
- Amgen
- Target Recruit Count
- 443
- Registration Number
- NCT00369733
STAAR-1 Clinical Study
Phase 4
Completed
- Conditions
- First Posted Date
- 2006-08-29
- Last Posted Date
- 2009-10-16
- Lead Sponsor
- Amgen
- Target Recruit Count
- 2000
- Registration Number
- NCT00369772
STIMULATE Study: Anemia Correction and Health-related Quality of Life (HRQoL) Outcomes in Elderly Chronic Kidney Disease (CKD) Patients
Phase 3
Terminated
- Conditions
- Interventions
- First Posted Date
- 2006-08-16
- Last Posted Date
- 2014-05-21
- Lead Sponsor
- Amgen
- Target Recruit Count
- 51
- Registration Number
- NCT00364845
A Dose Finding Study of KRN321(Darbepoetin Alfa) for the Treatment of Anemia in Subjects With Solid Tumor
Phase 2
Completed
- Conditions
- First Posted Date
- 2006-08-03
- Last Posted Date
- 2012-08-31
- Lead Sponsor
- Kyowa Kirin Co., Ltd.
- Target Recruit Count
- 120
- Registration Number
- NCT00359840
- Locations
- 🇯🇵
Tokai region, Aichi, Japan
🇯🇵Kanto region, Tochigi, Saitama, Tokyo, Kanagawa, Japan
🇯🇵Hokuriku region, Niigata, Ishikawa, Japan
RED-HF™ Trial - Reduction of Events With Darbepoetin Alfa in Heart Failure Trial
Phase 3
Completed
- Conditions
- Interventions
- First Posted Date
- 2006-07-31
- Last Posted Date
- 2022-11-08
- Lead Sponsor
- Amgen
- Target Recruit Count
- 2278
- Registration Number
- NCT00358215
- Locations
- 🇬🇧
Research Site, York, United Kingdom
Darbepoetin Alfa (Aranesp) Following Allogeneic Stem Cell Transplantation
Not Applicable
Completed
- Conditions
- First Posted Date
- 2006-07-21
- Last Posted Date
- 2009-03-13
- Lead Sponsor
- Dana-Farber Cancer Institute
- Target Recruit Count
- 31
- Registration Number
- NCT00355407
- Locations
- 🇺🇸
Dana-Farber Cancer Institute, Boston, Massachusetts, United States
A Double-blind Study of KRN321 for the Treatment of Anemia in Cancer Patients
Phase 3
Completed
- Conditions
- First Posted Date
- 2006-06-26
- Last Posted Date
- 2012-08-31
- Lead Sponsor
- Kyowa Kirin Co., Ltd.
- Target Recruit Count
- 200
- Registration Number
- NCT00344409
- Locations
- 🇯🇵
Shikoku region, Ehime, Japan
🇯🇵Kyusyu region, Fukuoka, Kagoshima, Japan
🇯🇵Chugoku region, Hiroshima, Tottori, Japan
A Study of Mircera in Anemic Patients With Non-Small Cell Lung Cancer Receiving First Line Chemotherapy.
Phase 2
Completed
- Conditions
- Interventions
- First Posted Date
- 2006-05-18
- Last Posted Date
- 2016-08-11
- Lead Sponsor
- Hoffmann-La Roche
- Target Recruit Count
- 153
- Registration Number
- NCT00327535
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