Interferon gamma-1b
- Generic Name
- Interferon gamma-1b
- Brand Names
- Actimmune
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 98059-61-1
- Unique Ingredient Identifier
- 21K6M2I7AG
- Background
Human Interferon gamma-1b (140 residues), produced from E. coli. Production of Actimmune is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein. Purification of the product is achieved by conventional column chromatography.
The sequence displayed is a cDNA sequence which codes for human interferon gamma, as described by Gray et. al. and not specifically interferon gamma 1b.
- Indication
Interferon gamma-1b is used for the treatment of Chronic granulomatous disease and Osteopetrosis.
- Associated Conditions
- Chronic Granulomatous Disease (CGD), Severe, malignant Osteopetrosis
- Associated Therapies
- -
The Effects of r-metHuIFN-Gamma on the Lungs of Patients With AIDS
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Amgen
- Target Recruit Count
- 12
- Registration Number
- NCT00002433
- Locations
- ๐บ๐ธ
New York Hosp - Cornell Med Ctr, New York, New York, United States
The Safety and Effectiveness of Injections of Human Recombinant Interferon-gamma in Patients With AIDS Who Have Taken Zidovudine
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-04
- Target Recruit Count
- 5
- Registration Number
- NCT00001112
- Locations
- ๐บ๐ธ
Cornell University A2201, New York, New York, United States
A Study of Tumor Necrosis Factor and Human Interferon-gamma in Patients With AIDS Related Complex
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-04
- Target Recruit Count
- 30
- Registration Number
- NCT00001004
- Locations
- ๐บ๐ธ
Univ of Washington, Seattle, Washington, United States
Phase I/II Study of Recombinant Human Interferon-gamma (rIFN-gamma) in HIV-Infected Children
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-03
- Target Recruit Count
- 20
- Registration Number
- NCT00000761
- Locations
- ๐บ๐ธ
The Children's Hosp. of Philadelphia IMPAACT CRS, Philadelphia, Pennsylvania, United States
๐บ๐ธTexas Children's Hosp. CRS, Houston, Texas, United States
Safety and Antifungal Activity of Recombinant Interferon-Gamma 1b (rIFN-Gamma 1b) Given With Standard Therapy in Patients With Cryptococcal Meningitis
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2009-06-03
- Lead Sponsor
- InterMune
- Target Recruit Count
- 60
- Registration Number
- NCT00012467
- Locations
- ๐บ๐ธ
Houston Veterans Administration Med Ctr, Houston, Texas, United States
๐บ๐ธUniv of Texas / Med School at Houston, Houston, Texas, United States
๐ต๐ชInstituto de Medicina Tropical, Lima, Peru
Drug Development Updates
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