Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This recombinant form differs from native interleukin-2 in the following ways: a) Aldesleukin is not glycosylated because it is derived from E. coli; b) the molecule has no N-terminal alanine; the codon for this amino acid was deleted during the genetic engineering procedure; c) the molecule has serine substituted for cysteine at amino acid position 125.
For treatment of adults with metastatic renal cell carcinoma.
Nyu Ny Nichd Crs, New York, New York, United States
Children's National Med. Ctr. Washington DC NICHD CRS, Washington, District of Columbia, United States
Usc La Nichd Crs, Los Angeles, California, United States
The Ctr For Blood Research Inc, Boston, Massachusetts, United States
Univ of Pittsburgh Med School, Pittsburgh, Pennsylvania, United States
Thomas Street Clinic C605-020 CRS, Houston, Texas, United States
Univ of Pittsburgh Med School, Pittsburgh, Pennsylvania, United States
Alabama Therapeutics CRS, Birmingham, Alabama, United States
University of Colorado Hospital CRS, Aurora, Colorado, United States
SUNY - Buffalo, Erie County Medical Ctr., Buffalo, New York, United States
Johns Hopkins Hosp, Baltimore, Maryland, United States
Hosp. of the Univ. of Pennsylvania CRS, Philadelphia, Pennsylvania, United States
Alabama Therapeutics CRS, Birmingham, Alabama, United States
USC CRS, Los Angeles, California, United States
Kobler Ctr. of Chelsea Westminster Hosp. C604-030 CRS, London, United Kingdom
UCLA CARE Center CRS, Los Angeles, California, United States
San Mateo County AIDS Program, San Mateo, California, United States
St. Louis ConnectCare, Infectious Diseases Clinic, Saint Louis, Missouri, United States
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