Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This recombinant form differs from native interleukin-2 in the following ways: a) Aldesleukin is not glycosylated because it is derived from E. coli; b) the molecule has no N-terminal alanine; the codon for this amino acid was deleted during the genetic engineering procedure; c) the molecule has serine substituted for cysteine at amino acid position 125.
For treatment of adults with metastatic renal cell carcinoma.
Ohio State University, Columbus, Ohio, United States
James Graham Brown Cancer Center, Louisville, Kentucky, United States
USC/Kenneth Norris Comprehensive Cancer Center, Los Angeles, California, United States
University of Colorado Cancer Center, Aurora, Colorado, United States
Hematology Oncology Associates of IL, Chicago, Illinois, United States
Pudget Sound Cancer Center-Seattle, Seattle, Washington, United States
Minnesota Oncology Hematology, PA, Minneapolis, Minnesota, United States
Children Armand Trousseau Hospital, Paris, France
University of Washington (UW), Seattle, Washington, United States
Fred Hutchinson Cancer Research Center, Seattle, Washington, United States
Rady Children's Hospital - San Diego, San Diego, California, United States
UCSF Medical Center-Parnassus, San Francisco, California, United States
UCSF Medical Center-Mission Bay, San Francisco, California, United States
Univ. of Hawaii at Manoa, Leahi Hosp., Honolulu, Hawaii, United States
UCLA CARE Center CRS, Los Angeles, California, United States
UC Davis Medical Center, Sacramento, California, United States
St. Louis ConnectCare, Infectious Diseases Clinic, St Louis, Missouri, United States
Harbor-UCLA Med. Ctr. CRS, Torrance, California, United States
Case CRS, Cleveland, Ohio, United States
Duke Univ. Med. Ctr. Adult CRS, Durham, North Carolina, United States
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.