Alpha-1-proteinase inhibitor
- Generic Name
- Alpha-1-proteinase inhibitor
- Brand Names
- Aralast, Glassia, Prolastin, Prolastin-C, Respreeza, Zemaira
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 9041-92-3
- Unique Ingredient Identifier
- F43I396OIS
- Background
Human alpha-1 proteinase inhibitor or alpha-1-antitrypsin, prepared from human plasma via Cohn alcohol fractionation followed by PEG and zinc chloride fractionation.
- Indication
For chronic augmentation and maintenance therapy in individuals with alpha1-proteinase inhibitor (A1-PI) deficiency and clinical evidence of emphysema.
- Associated Conditions
- Emphysema
- Associated Therapies
- Augmentation, Maintenance therapy
Establishment and characterization of mouse metabolic dysfunction-associated ...
Study establishes MASH-HCC organoids using CDAHFD-fed mice, finding multi-biotics enhance Lenvatinib sensitivity but not prevent resistance. RNA-seq identifies 30 DEGs, including Slc5a8, Vnn3, and Mcm5, linked to metabolic and immune pathways. Enriched pathways like NF-κB and EMT suggest multi-biotics' role in modulating drug response, with potential for adjunct therapy in HCC.
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