Desmoteplase
- Generic Name
- Desmoteplase
- Brand Names
- -
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 145137-38-8
- Unique Ingredient Identifier
- T36L245S3T
- Background
Desmoteplase is a chemical in the saliva of vampire bats. It activates plasminogen to the serine protease, plasmin. Plasmin acts by breaking down fibrin blood clots. When a vampire bat bites its victim, it secretes an enzyme that prevents the blood from clotting. The enzyme is called DSPA (Desmodus rotundus salivary plasminogen activator) and scientists are using DSPA as stroke and heart attack medication. Desmoteplase is a recombinant form of vampire bat DSPA (Salivary plasminogen activator alpha 1).
- Indication
Investigated for use/treatment in cerebral ischemia and strokes.
- Associated Conditions
- -
- Associated Therapies
- -
Clinical Study of Desmoteplase in Japanese Patients With Acute Ischemic Stroke
- First Posted Date
- 2010-04-15
- Last Posted Date
- 2021-08-31
- Lead Sponsor
- Lundbeck Japan K. K.
- Target Recruit Count
- 48
- Registration Number
- NCT01104467
- Locations
- 🇯🇵
JP024, Kagoshima, Japan
🇯🇵JP011, Kawasaki, Japan
🇯🇵JP004, Sendai, Japan
Efficacy and Safety Study of Desmoteplase to Treat Acute Ischemic Stroke (DIAS-4)
- First Posted Date
- 2009-03-06
- Last Posted Date
- 2017-03-16
- Lead Sponsor
- H. Lundbeck A/S
- Target Recruit Count
- 270
- Registration Number
- NCT00856661
- Locations
- 🇺🇸
US077, Lebanon, New Hampshire, United States
🇺🇸US064, Shreveport, Louisiana, United States
🇺🇸US063, Fairfield, Connecticut, United States
Efficacy and Safety Study of Desmoteplase to Treat Acute Ischemic Stroke
- First Posted Date
- 2008-11-14
- Last Posted Date
- 2015-09-18
- Lead Sponsor
- H. Lundbeck A/S
- Target Recruit Count
- 492
- Registration Number
- NCT00790920
- Locations
- 🇦🇺
AU006, Clayton, Australia
🇫🇷FR012, Limoges, France
🇮🇳IN008, Hyderabad, India
Desmoteplase in Acute Ischemic Stroke (DIAS)
- First Posted Date
- 2008-03-19
- Last Posted Date
- 2008-03-19
- Lead Sponsor
- PAION Deutschland GmbH
- Target Recruit Count
- 104
- Registration Number
- NCT00638781
- Locations
- 🇩🇪
Prof. Dr. Werner Hacke, Heidelberg, Germany
Dose Escalation of Desmoteplase in Acute Ischemic Stroke (DEDAS)
- First Posted Date
- 2008-03-19
- Last Posted Date
- 2008-03-19
- Lead Sponsor
- PAION Deutschland GmbH
- Target Recruit Count
- 38
- Registration Number
- NCT00638248
Study of Desmoteplase (International Nonproprietary Name [INN]) in Acute Ischemic Stroke (DIAS-2)
- First Posted Date
- 2005-05-27
- Last Posted Date
- 2012-03-20
- Lead Sponsor
- Forest Laboratories
- Target Recruit Count
- 193
- Registration Number
- NCT00111852
- Locations
- 🇨🇦
Vancouver General Hospital, Vancouver, British Columbia, Canada
🇺🇸Melbourne Internal Medicine Associates (MIMA), Melbourne, Florida, United States
🇺🇸The Methodist Hospital, Houston, Texas, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.