Leptin

Weight loss via lifestyle intervention improved inflammatory markers in women with HER2-negative breast cancer, according to the Breast Cancer Weight Loss (BWEL) trial. The intervention led to a 5.7% weight loss at 1 year, significantly improving metabolic hormones and inflammatory biomarkers.

KFF Health News highlights recent health research: RNA interference therapy shows promise for chronic hepatitis B; beta-blockers may slow Huntington's disease progression; new obesity drug combo uses leptin; HPV vaccines linked to drop in cervical cancer deaths; prior fractures increase osteoporosis risk; chikungunya's global impact; men more likely to develop COVID-19 pneumonia.

Men with CVD risk factors experience cognitive decline a decade earlier than women, per a study by Imperial College London and Cardiff University. The research, based on 34,425 UK Biobank participants, found significant brain health deterioration in men from mid-50s to mid-70s, while women are most vulnerable from mid-60s to mid-70s. The study highlights that cardiovascular risk impacts cognitive functions independently of genetic predisposition.

A three-neuron circuit connects hunger-signaling hormone to jaw movements of chewing, identified by Rockefeller University researchers. BDNF neurons in the ventromedial hypothalamus, when inhibited, lead to overeating and chewing motions without food. Activation suppresses food intake and chewing, suggesting a reflex-like control of feeding.

Lipodystrophies reveal insights into metabolic syndrome, consequences of adipose tissue overloading, and treatment strategies including leptin replacement and gene therapy.