Irofulven

Generic Name
Irofulven
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C15H18O3
CAS Number
158440-71-2
Unique Ingredient Identifier
6B799IH05A
Background

A novel anti-cancer compound synthesized by scientists at the University of California, San Diego more than a decade ago from toxins of the poisonous jack-o-lantern mushroom, has been granted โ€œfast trackโ€ status by the U.S. Food and Drug Administration (FDA) after demonstrating promise against one of the most deadly cancers.

MGI-114 (Irofulven) is currently being developed by MGI PHARMA, Inc., an emerging oncology-focused pharmaceutical company based in Minneapolis. Phase III clinical trials involving the drug have been underway since early 2001 at sites in the U.S. and Europe.

Indication

Investigated for use/treatment in brain cancer, breast cancer, endometrial cancer, liver cancer, lung cancer, ovarian cancer, pancreatic cancer, pediatric indications, prostate cancer, and sarcoma.

Associated Conditions
-
Associated Therapies
-

Irofulven in Treating Patients With Recurrent or Persistent Ovarian, Fallopian Tube, or Peritoneal Cancer

First Posted Date
2004-04-13
Last Posted Date
2013-06-20
Lead Sponsor
National Cancer Institute (NCI)
Registration Number
NCT00019552
Locations
๐Ÿ‡บ๐Ÿ‡ธ

Medicine Branch, Bethesda, Maryland, United States

Irofulven in Treating Patients With Persistent or Recurrent, Refractory Endometrial Cancer

Phase 2
Completed
Conditions
First Posted Date
2004-03-31
Last Posted Date
2013-05-27
Lead Sponsor
Gynecologic Oncology Group
Registration Number
NCT00005031
Locations
๐Ÿ‡บ๐Ÿ‡ธ

Kimmel Cancer Center of Thomas Jefferson University - Philadelphia, Philadelphia, Pennsylvania, United States

๐Ÿ‡บ๐Ÿ‡ธ

University of Pennsylvania Cancer Center, Philadelphia, Pennsylvania, United States

๐Ÿ‡บ๐Ÿ‡ธ

Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States

and more 37 locations

Irofulven in Treating Children With Recurrent or Refractory Solid Tumors

First Posted Date
2004-02-09
Last Posted Date
2013-02-05
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
12
Registration Number
NCT00003370
Locations
๐Ÿ‡บ๐Ÿ‡ธ

Hackensack University Medical Center, Hackensack, New Jersey, United States

๐Ÿ‡บ๐Ÿ‡ธ

Children's Hospital of Columbus, Columbus, Ohio, United States

๐Ÿ‡บ๐Ÿ‡ธ

Dana-Farber Cancer Institute, Boston, Massachusetts, United States

and more 53 locations

Irofulven Compared With Fluorouracil in Treating Patients With Pancreatic Cancer

Phase 3
Completed
Conditions
Interventions
First Posted Date
2004-01-15
Last Posted Date
2012-12-24
Lead Sponsor
Eisai Inc.
Target Recruit Count
158
Registration Number
NCT00033735
Locations
๐Ÿ‡บ๐Ÿ‡ธ

MGI Pharma, Incorporated, Bloomington, Minnesota, United States

Irofulven in Treating Patients With Recurrent or Metastatic Gastric Cancer

Phase 2
Completed
Conditions
First Posted Date
2003-06-06
Last Posted Date
2013-05-15
Lead Sponsor
Cancer Therapeutics Research Group
Registration Number
NCT00062257
Locations
๐Ÿ‡ฐ๐Ÿ‡ท

Yonsei Cancer Center at Yonsei University Medical Center, Seoul, Korea, Republic of

๐Ÿ‡ฆ๐Ÿ‡บ

Sydney Cancer Centre at Royal Prince Alfred Hospital, Sydney, New South Wales, Australia

๐Ÿ‡ธ๐Ÿ‡ฌ

Johns Hopkins - Singapore, Singapore, Singapore

and more 3 locations

Irofulven in Treating Patients With Recurrent or Persistent Ovarian Epithelial or Primary Peritoneal Cancer

First Posted Date
2003-01-28
Last Posted Date
2019-07-24
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
61
Registration Number
NCT00053365
Locations
๐Ÿ‡บ๐Ÿ‡ธ

Gynecologic Oncology Group, Philadelphia, Pennsylvania, United States

Irofulven in Treating Patients With Metastatic Breast Cancer

Phase 2
Completed
Conditions
Interventions
First Posted Date
2003-01-27
Last Posted Date
2013-02-11
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
32
Registration Number
NCT00003796
Locations
๐Ÿ‡บ๐Ÿ‡ธ

University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States

Chemotherapy in Treating Patients With Progressive or Recurrent Brain Tumors

Phase 1
Completed
Conditions
First Posted Date
2003-01-27
Last Posted Date
2013-06-24
Lead Sponsor
New Approaches to Brain Tumor Therapy Consortium
Registration Number
NCT00012038
Locations
๐Ÿ‡บ๐Ÿ‡ธ

Emory University Hospital - Atlanta, Atlanta, Georgia, United States

๐Ÿ‡บ๐Ÿ‡ธ

Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States

๐Ÿ‡บ๐Ÿ‡ธ

Comprehensive Cancer Center at Wake Forest University, Winston-Salem, North Carolina, United States

and more 7 locations
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