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Cariprazine

Generic Name
Cariprazine
Brand Names
Vraylar, Reagila
Drug Type
Small Molecule
Chemical Formula
C21H32Cl2N4O
CAS Number
839712-12-8
Unique Ingredient Identifier
F6RJL8B278
Background

Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary. It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT receptors and as an antagonist at serotonin 5-HT receptors. Cariprazine has been investigated in a variety of psychiatric disorders, including schizophrenia, bipolar disorders, and major depressive disorder. Cariprazine gained its first global approval in the US in September 2015 and was later approved by Health Canada in April 2022. It is currently used to treat schizophrenia, and manic or mixed episodes and depressive episodes associated with bipolar I disorder.

Indication

Cariprazine is indicated for the treatment of schizophrenia in adults to manage both positive and negative symptoms. It is also indicated to monotherapy for acute management of manic or mixed episodes associated with bipolar I disorder (bipolar mania) in adults, and acute management of depressive episodes associated with bipolar I disorder (bipolar depression) in adults.

Associated Conditions
Bipolar Disorder With Manic or Mixed Episodes, Depressive Episodes, Schizophrenia
Associated Therapies
-

A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.

Phase 3
Recruiting
Conditions
Depression
Bipolar I Disorder
Interventions
Drug: Placebo
Drug: Cariprazine
First Posted Date
2021-03-02
Last Posted Date
2025-01-09
Lead Sponsor
AbbVie
Target Recruit Count
380
Registration Number
NCT04777357
Locations
🇺🇸

Beaumont Psychiatric Clinic /ID# 267484, Beaumont, Texas, United States

🇺🇸

Pillar Clinical Research /ID# 226504, Bentonville, Arkansas, United States

🇺🇸

Advanced Research Center /ID# 227073, Anaheim, California, United States

and more 65 locations
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