Cangrelor
- Generic Name
- Cangrelor
- Brand Names
- Kengreal, Kengrexal
- Drug Type
- Small Molecule
- Chemical Formula
- C17H25Cl2F3N5O12P3S2
- CAS Number
- 163706-06-7
- Unique Ingredient Identifier
- 6AQ1Y404U7
- Background
Cangrelor is an intravenous, direct-acting, reversible P2Y12 inhibitor for patients undergoing percutaneous coronary intervention (PCI) who have not been yet treated by oral P2Y12 inhibitors. An advantage Cangrelor provides over oral P2Y12 inhibitors (such as prasugrel, ticagrelor, and clopidogrel) is that it is an active drug not requiring metabolic convers...
- Indication
For use as an adjunct to percutaneous coronary intervention (PCI) for reducing the risk of periprocedural myocardial infarction (MI), repeat coronary revascularization, and stent thrombosis (ST) in patients in who have not been treated with a P2Y12 platelet inhibitor and are not being given a glycoprotein IIb/IIIa inhibitor.
- Associated Conditions
- Coronary Revascularization, Peri-procedural Myocardial Infarction, Thrombosis (Stent Thrombosis)
- Associated Therapies
- -
Intravenous CAngrelor in High-bleeding Risk Patients Undergoing percutaneouS Coronary Intervention (ICARUS) Registry
- Conditions
- Interventions
- First Posted Date
- 2022-08-18
- Last Posted Date
- 2022-08-18
- Lead Sponsor
- Universita degli Studi di Genova
- Target Recruit Count
- 900
- Registration Number
- NCT05505591
- Locations
- 🇮🇹
Università degli Studi della Campania "Luigi Vanvitelli", Caserta, Italy
🇮🇹University of Genoa, Genova, Italy
Pharmacodynamic Effects of Cangrelor in ACS or CCS Patients Undergoing PCI (POMPEII Registry)
- Conditions
- First Posted Date
- 2021-03-10
- Last Posted Date
- 2024-03-05
- Lead Sponsor
- Federico II University
- Target Recruit Count
- 100
- Registration Number
- NCT04790032
- Locations
- 🇮🇹
University Federico II of Naples, Napoli, Italy
Pharmacodynamic and Pharmacokinetic of Switching From Cangrelor to Prasugrel in ACS Patients Undergoing PCI
- Conditions
- Interventions
- First Posted Date
- 2020-12-16
- Last Posted Date
- 2024-03-20
- Lead Sponsor
- University of Florida
- Target Recruit Count
- 359
- Registration Number
- NCT04668144
- Locations
- 🇺🇸
University of Florida Jacksonville, Jacksonville, Florida, United States
REperfusion With P2Y12 Inhibitors in Addition to mEchanical thRombectomy for perFUsion Imaging Selected Acute Stroke patiEnts
- First Posted Date
- 2020-12-14
- Last Posted Date
- 2024-02-16
- Lead Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
- Target Recruit Count
- 368
- Registration Number
- NCT04667078
- Locations
- 🇫🇷
CHU Lyon, Lyon, France
🇫🇷CHU Bordeaux, Bordeaux, France
🇫🇷CHRU Lille, Lille, France
PD and PK Profiles of Switching Between Cangrelor and Ticagrelor Following Ticagrelor Pre-treatment
- First Posted Date
- 2020-11-18
- Last Posted Date
- 2023-05-16
- Lead Sponsor
- University of Florida
- Target Recruit Count
- 22
- Registration Number
- NCT04634162
- Locations
- 🇺🇸
University of Florida Jacksonville, Jacksonville, Florida, United States
Dutch Cangrelor Registry
- First Posted Date
- 2019-10-24
- Last Posted Date
- 2020-07-28
- Lead Sponsor
- Isala
- Target Recruit Count
- 250
- Registration Number
- NCT04138641
- Locations
- 🇳🇱
R.S. Hermanides, Zwolle, Overijssel, Netherlands
Maintenance Of aNtiplatElet Therapy in Patients With Coronary Stenting Undergoing Surgery (MONET BRIDGE)
- First Posted Date
- 2019-03-05
- Last Posted Date
- 2019-03-05
- Lead Sponsor
- Ospedale Santa Croce-Carle Cuneo
- Target Recruit Count
- 140
- Registration Number
- NCT03862651
Dual Antiplatelet Therapy For Shock Patients With Acute Myocardial Infarction
- Conditions
- Interventions
- First Posted Date
- 2018-06-11
- Last Posted Date
- 2024-12-16
- Lead Sponsor
- Faculty Hospital Kralovske Vinohrady
- Target Recruit Count
- 605
- Registration Number
- NCT03551964
- Locations
- 🇨🇿
University Hospital Kralovske Vinohrady, Prague, Please Select, Czechia
🇨🇿St. Anne's University Hospital Brno, Brno, Czechia
🇨🇿Department of Cardiology, University Hospital Brno-Bohunice, Brno, Czechia
Add-on Cangrelor in STEMI-triggered Cardiac Arrest
- First Posted Date
- 2017-09-06
- Last Posted Date
- 2017-09-13
- Lead Sponsor
- Medical University of Vienna
- Target Recruit Count
- 60
- Registration Number
- NCT03273075
- Locations
- 🇦🇹
Medical University of Vienna, Vienna, Austria
Platelet Inhibition With Cangrelor and Crushed Ticagrelor in STEMI
- Conditions
- Interventions
- First Posted Date
- 2017-08-14
- Last Posted Date
- 2020-09-09
- Lead Sponsor
- University of Florida
- Target Recruit Count
- 50
- Registration Number
- NCT03247738
- Locations
- 🇺🇸
University of Florida, Jacksonville, Florida, United States
Drug Development Updates
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