Lonafarnib
- Generic Name
- Lonafarnib
- Brand Names
- Zokinvy
- Drug Type
- Small Molecule
- Chemical Formula
- C27H31Br2ClN4O2
- CAS Number
- 193275-84-2
- Unique Ingredient Identifier
- IOW153004F
- Background
Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cutaneous effects, lipoatrophy, alopecia, a...
- Indication
Lonafarnib is a farnesyltransferase inhibitor indicated in patients aged 12 months and older with a body surface area of at least 0.39 m to reduce the risk of mortality associated with Hutchinson-Gilford progeria syndrome (HGPS). It is also indicated in this same population for the treatment of processing-deficient progeroid laminopathies that either involve...
- Associated Conditions
- Death, Hutchinson-Gilford Progeria Syndrome, Processing-deficient Progeroid Laminopathies
- Associated Therapies
- -
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.