Secretin human

Generic Name
Secretin human
Brand Names
Chirhostim
Drug Type
Biotech
Chemical Formula
-
CAS Number
108153-74-8
Unique Ingredient Identifier
A0426J905J
Background

Human secretin is a gastrointestinal peptide hormone that regulates secretions in the stomach, pancreas, and liver. The hormone is produced from the enterochromaffin cells in the duodenum in response to the duodenal content with the pH less than 4.5 . The main action of secretin is to stimulate the pancreas to secrete pancreatic juice for pH regulation in the small intestines. Secretin is also responsible in body fluid homeostasis and bile production. Although it is a gastrointestinal hormone, secretin is also considered as a neuropeptide hormone since it is also expressed in the central nervous system .

Purified synthetic human secretin, also referred to as RG1068, is available as an intravenous injection under the market name ChiRhoStim ® in the U.S.. It contains an amino acid sequence identical to the naturally occurring hormone consisting of 27 amino acids that supports α-helical formation . The carboxyl-terminal amino acid, valine, is amidated. Synthetic human secretin displays equivalent biological activity and properties as naturally-occurring secretin . It is indicated for the stimulation of the pancreatic and gastric secretions to aid in the diagnosis of pancreatic exocrine dysfunction and the diagnosis of gastrinoma, and facilitate the identification of the ampulla of Vater and accessory papilla during endoscopic retrograde cholangiopancreatography (ERCP).

Indication

Indicated for the stimulation of:

Associated Conditions
Gastrinoma, Pancreatic exocrine dysfunction
Associated Therapies
-

PCI Pharma Services and ChiRhoClin partner to prevent shortage of pancreatic drug

PCI Pharma Services collaborates with ChiRhoClin to prevent a shortage of ChiRhoStim, a diagnostic drug for pancreatic disease and cancer. A high-priority project led to a stable supply of ChiRhoStim in the U.S., with PCI handling manufacturing, testing, and distribution. ChiRhoClin plans to continue using PCI as its primary partner for ChiRhoStim production.
contractpharma.com
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PCI, ChiRhoClin Partner To Avoid Shortage Of Critical Diagnostic Drug

PCI Pharma Services collaborates with ChiRhoClin Inc. to prevent a shortage of ChiRhoStim, a diagnostic drug for pancreatic disease and cancer, ensuring a stable supply in the U.S. The partnership expedited the drug's release by three months through streamlined manufacturing and distribution processes.
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