Tocopherol

Generic Name
Tocopherol
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
-
CAS Number
1406-66-2
Unique Ingredient Identifier
R0ZB2556P8
Background

Tocopherol exists in four different forms designated as α, β, δ, and γ. They present strong antioxidant activities, and it is determined as the major form of vitamin E. Tocopherol, as a group, is composed of soluble phenolic compounds that consist of a chromanol ring and a 16-carbon phytyl chain. The classification of the tocopherol molecules is designated d...

Indication

Tocopherol can be used as a dietary supplement for patients with a deficit of vitamin E; this is mainly prescribed in the alpha form. Vitamin E deficiency is rare, and it is primarily found in premature babies of very low birth weight, patients with fat malabsorption or patients with abetalipoproteinemia.
...

Associated Conditions
Vitamin E Deficiency
Associated Therapies
Skin Care
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Parkinson's Disease Trials Could Benefit From Simon Two-stage Design

Simon 2-Stage futility trial design is feasible for early Parkinson's disease treatments, potentially accelerating discovery of new treatments by reducing time, cost, and sample size. The design uses an interim analysis to stop ineffective treatments early, focusing on a 12-month follow-up and a five-point worsening on the UPDRS motor score as primary outcome. However, it has limitations like longer recruitment periods and a higher probability of falsely stopping trials.

Feasibility of Simon 2-Stage Futility Trials in Early Parkinson Disease

Futility trials using the Simon 2-Stage methodology are feasible in Parkinson disease (PD), with a proposed 5-point worsening on the UPDRS motor score as the primary outcome measure and a 12-month follow-up, requiring a sample size of less than 200 participants.
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