CDI, a leading cause of healthcare-associated diarrhea, requires novel antibiotics. Cadazolid, a hybrid antibiotic, shows potent in vitro activity against relevant C. difficile strains, avoids native gut flora, and is gut-restricted with minimal systemic circulation.
Cadazolid, a hybrid antibiotic, shows potent in vitro activity against hypervirulent and resistant Clostridioides difficile strains, while sparing native gut flora, designed for gut-restricted use.