Capivasertib

Generic Name
Capivasertib
Brand Names
Truqap
Drug Type
Small Molecule
Chemical Formula
C21H25ClN6O2
CAS Number
1143532-39-1
Unique Ingredient Identifier
WFR23M21IE
Background

Capivasertib has been investigated for the treatment of Metastatic Breast Cancer.

Associated Conditions
-
Associated Therapies
-
formularywatch.com
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Optum Rx Switches Up Humira Biosimilar Coverage for 2025

Optum Rx prefers Amgen’s Amjevita over Sandoz’s Hyrimoz and Cyltezo on its 2025 commercial formularies, aiming to reduce costs and improve affordability. Humira remains on the formulary but with stricter controls. Biosimilars, including Humira’s, have struggled with adoption despite cost savings potential. Optum Rx also adds and removes various oncology and CNS medications for 2025.

Switches Up Humira Biosimilar Coverage for 2025

Optum Rx prefers Amgen’s Amjevita over Sandoz’s Hyrimoz and Cyltezo on its 2025 commercial formularies, aiming to reduce costs and improve affordability. Humira remains on the formulary but is subject to prior authorization. Biosimilars have struggled with low adoption despite cost advantages, but large PBMs like CVS Health are shifting towards biosimilars. Optum Rx also adds and removes various oncology and CNS medications from its 2025 formulary.
finance.yahoo.com
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Pharma Stock Roundup: RHHBY to Buy PSTX, MRK, AZN See Pipeline Success

Roche to acquire Poseida Therapeutics for $1 billion. Merck, AstraZeneca, and Novartis see success in new drug studies. Novartis' Kisqali approved for broader breast cancer treatment in EU.
pipelinereview.com
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Truqap combination in PTEN-deficient metastatic hormone-sensitive prostate cancer

CAPItello-281 Phase III trial results show AstraZeneca's Truqap (capivasertib) + abiraterone + ADT significantly improves rPFS in PTEN-deficient mHSPC patients, with early OS trend improvement. Trial continues for OS assessment.
koreabiomed.com
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Truqap emerges as new hope for treating HR+/HER2- breast cancer

Truqap, the first AKT inhibitor, has arrived in Korea, offering new hope for HR+/HER2- breast cancer patients with PIK3CA, AKT1, and PTEN mutations. Despite its potential, challenges like the domestic diagnostic environment and drug reimbursement limit its impact. Professor Park Kyong-hwa highlights unmet needs in HR+/HER2- treatment, Truqap's clinical benefits, and the importance of genetic analysis for precision medicine.
pmlive.com
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AstraZeneca announces positive results for Truqap in phase 3 prostate cancer study

AstraZeneca's AKT inhibitor Truqap showed significant improvement in radiographic progression-free survival in PTEN-deficient metastatic hormone-sensitive prostate cancer patients, with an early trend towards overall survival improvement.

Truqap Combination Shines in Phase III Trial for Prostate Cancer

AstraZeneca's Phase III CAPItello-281 trial showed Truqap (capivasertib) + abiraterone + ADT improved rPFS in PTEN-deficient metastatic hormone-sensitive prostate cancer. Early OS signs also suggest benefit, with ongoing trial for further assessment. Truqap + Faslodex was approved in the EU for ER-positive, HER2-negative advanced breast cancer with PIK3CA, AKT1, or PTEN alterations.

AstraZeneca claims phase 3 success with combination therapy for prostate cancer

AstraZeneca's CAPItello-281 phase 3 trial showed significant improvements in radiographic progression-free survival (rPFS) with Truqap (capivasertib) combined with Zytiga (abiraterone) and ADT in PTEN-deficient de novo metastatic hormone-sensitive prostate cancer patients, compared to Zytiga and ADT alone. The trial, involving over 1,000 patients, marks the first AKT inhibitor combination to demonstrate benefit in this specific form of prostate cancer, with ongoing assessment for overall survival.

AstraZeneca reports results from trial of combination therapy for prostate cancer

AstraZeneca's Phase III CAPItello-281 trial showed Truqap improved radiographic progression-free survival (rPFS) when combined with abiraterone and androgen deprivation therapy (ADT) for PTEN-deficient de novo metastatic hormone-sensitive prostate cancer. The combination also showed a promising trend towards improved overall survival (OS) compared to abiraterone, ADT, and placebo.
firstwordpharma.com
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AstraZeneca's AKT inhibitor Truqap hits main goal of prostate cancer study

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