Telcagepant
- Generic Name
- Telcagepant
- Brand Names
- -
- Drug Type
- Small Molecule
- Chemical Formula
- C26H27F5N6O3
- CAS Number
- 781649-09-0
- Unique Ingredient Identifier
- D42O649ALL
- Background
Telcagepant has been investigated for the treatment of Migraine. It is an antagonist of the receptor for calcitonin gene-related peptide (CGRP), a primary neuropeptide involved in the pathophysiology of migraine. CGRP and its receptors are found in areas of the central and peripheral nervous system that are important for the transmission of migraine pain. Du...
- Associated Conditions
- -
- Associated Therapies
- -
Positron Emission Tomography (PET) Study of Brain Calcitonin Gene-Related Peptide (CGRP) Receptor Occupancy After Telcagepant Administration (MK-0974-067)
- First Posted Date
- 2011-03-15
- Last Posted Date
- 2019-04-02
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 10
- Registration Number
- NCT01315847
A Study to Assess the Safety, Tolerability, and Effects of MK-0974 (Telcagepant) on Exercise Tolerance in Patients With Stable Angina (MK-0974-014)
Phase 1
Completed
- Conditions
- Interventions
- First Posted Date
- 2011-02-11
- Last Posted Date
- 2018-10-18
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 64
- Registration Number
- NCT01294709
Telcagepant for Prevention of Menstrually Related Migraine in Female Participants With Episodic Migraine (MK-0974-065)
- First Posted Date
- 2010-05-18
- Last Posted Date
- 2018-10-23
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 4548
- Registration Number
- NCT01125774
A Study to Test the Safety and Effectiveness of MK-0974 (Telcagepant) Co-administered With Ibuprofen or Acetaminophen in Patients With Migraines With or Without Aura (MK-0974-046)
Phase 2
Completed
- Conditions
- Interventions
- First Posted Date
- 2008-09-25
- Last Posted Date
- 2018-10-22
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 683
- Registration Number
- NCT00758836
Telcagepant (MK-0974) Treatment of Migraine in Participants With Stable Vascular Disease (MK-0974-034)
- First Posted Date
- 2008-04-21
- Last Posted Date
- 2018-10-19
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 165
- Registration Number
- NCT00662818
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