Nafamostat

Generic Name
Nafamostat
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C19H17N5O2
CAS Number
81525-10-2
Unique Ingredient Identifier
Y25LQ0H97D
Background

Nafamostat is a synthetic serine protease inhibitor that is commonly formulated with hydrochloric acid due to its basic properties. It has been used in trials studying the prevention of Liver Transplantation and Postreperfusion Syndrome. The use of nafamostat in Asian countries is approved as an anticoagulant therapy for patients undergoing continuous renal ...

Indication

Used as an anticoagulant in patients with disseminative blood vessel coagulation, hemorrhagic lesions, and hemorrhagic tendencies. It prevents blood clot formation during extracorporeal circulation in patients undergoing continuous renal replacement therapy and extra corporeal membrane oxygenation.

Associated Conditions
-
Associated Therapies
-
gurufocus.com
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Ensysce Biosciences Announces Commercial Supplier for Breakthrou

Ensysce Biosciences secures GMP nafamostat supply for PF614-MPAR, accelerating clinical development and pipeline expansion with Aurore Life Sciences.
morningstar.com
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Ensysce Biosciences Announces Commercial Supplier for Breakthrough Overdose ...

Ensysce Biosciences secures GMP nafamostat supply for PF614-MPAR, ensuring supply chain security and accelerating clinical development.
stocktitan.net
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Ensysce Biosciences Secures Critical Supply Deal for Breakthrough Overdose Protection

Ensysce Biosciences secured future supply of GMP nafamostat from Aurore Life Sciences for PF614-MPAR, its overdose protection drug product, ensuring the supply chain and allowing reference to Aurore's Drug Master File. This agreement also benefits other nafamostat-based programs.
biospace.com
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Ensysce Biosciences Completes Significant Milestone, Dosing First Subjects in ...

Ensysce Biosciences treated first group in PF614-MPAR-102 study, aiming for early interim data in 1Q 2025. PF614-MPAR received FDA Breakthrough Therapy designation, supported by a $14 million NIDA award. Ensysce targets reducing opioid abuse and overdose with its TAAP and MPAR platforms.
stocktitan.net
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Ensysce Biosciences Launches Key Trial for Breakthrough Opioid Drug, Backed by $14M NIDA Grant

Ensysce Biosciences initiates dosing in PF614-MPAR-102 study, evaluating oxycodone and PF614 pharmacokinetics with nafamostat, funded by a $14 million NIDA award, with interim data expected in Q1 2025.
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