Clazakizumab failed to meet primary efficacy outcomes in the IMAGINE Phase 3 trial for chronic active antibody-mediated rejection (caAMR) in kidney transplant recipients, showing no difference in eGFR change from baseline at week 52 compared to placebo, with no safety concerns observed.
Clazakizumab, targeting IL-6, failed to meet primary efficacy outcomes in the IMAGINE Phase 3 trial for chronic active antibody-mediated rejection in kidney transplant recipients, according to a final analysis. No significant difference in kidney function was observed between clazakizumab and placebo, with no safety concerns reported.