Lutetium Lu-177

Generic Name
Lutetium Lu-177
Brand Names
Lutathera, Lumark, EndolucinBeta, Lutetium (177Lu) chloride Billev (previously Illuzyce)
Drug Type
Small Molecule
Chemical Formula
Lu
CAS Number
14265-75-9
Unique Ingredient Identifier
BRH40Y9V1Q
Associated Conditions
Neuroendocrine Tumors
Associated Therapies
-
pharmacytimes.com
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Nuclear Isotopes Could Help Address Challenges in Oncology Clinical Trials

Cancer trials face a 95% failure rate despite advancements like CAR T-cell therapies. Nuclear isotopes, used for imaging and therapy, show promise in targeting cancer cells while sparing healthy tissues. Actinium-225 and Lutetium-177 are particularly promising, with challenges including supply, delivery precision, and patient-specific dosing. AI could optimize isotope production, delivery, and personalized treatment plans, though data limitations and high costs remain significant hurdles.
globenewswire.com
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Medical Isotope Market to Reach USD 12.15 Billion by 2032

The Global Medical Isotope Market was valued at USD 5.66 billion in 2023 and is projected to reach USD 12.15 billion by 2032, growing at a CAGR of 8.87% driven by increased applications in diagnostics and therapy, particularly in cancer treatment. Key isotopes include technetium-99m, iodine-131, and lutetium-177. The market is influenced by advancements in nuclear medicine, imaging technologies, and personalized treatments, with challenges in supply chain and transportation due to radioactive nature. Major players include GE Healthcare, Jubilant Radiopharma, and Mallinckrodt Pharmaceuticals. North America dominates the market, while Asia-Pacific shows the fastest growth.
thenewsminute.com
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The Hidden Weapon in Cancer Care: How Nuclear Medicine is Revolutionizing Oncology

Nuclear medicine integrates diagnostic and therapeutic capabilities in oncology, using radiopharmaceuticals for precise cancer detection and treatment. It offers early diagnosis, targeted radiation, and personalized care, revolutionizing cancer diagnostics and treatment. Recent innovations, including AI and theranostics, enhance outcomes, though challenges like accessibility persist.
cbc.ca
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B.C. man calls for federal government to cover costly, life-saving cancer treatment

Pluvicto, a new prostate cancer treatment using lutetium-177, costs $27,000 per dose, totaling $135,000 for an average five-dose treatment. The pan-Canadian Pharmaceutical Alliance (pCPA) ended negotiations with Novartis, leaving patients to fund the treatment themselves. Health Canada approved Pluvicto in 2022, but coverage is unavailable in B.C. without third-party insurance or private payment. Patients and advocates call for renewed negotiations to make the treatment accessible.
nature.com
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Sex differences of fall-risk-increasing drugs in the middle-aged and elderly

101,746 AE reports analyzed, 68,492 (67.3%) female, 32,547 (32.0%) male; average age 69.8 ± 11.5 (female), 71.5 ± 11.2 (male). Report numbers fluctuated since 2004, peaking 2010-2012 and 2018-2019. Most reports from America (62.3% female, 55.4% male), mainly hospitalization (51.3% female, 51.2% male). Multiple sclerosis most reported AE (14.2% female, 6.2% male). Signals detected using ROR and BCPNN algorithms; top signals varied by sex. Sex differences in signal numbers noted in 2nd-level ATC classes. F/M ratio analysis on shared signals showed 33 positive for females, 38 for males, 48 no difference. Specific drugs showed stronger associations with falls in one sex over the other across various ATC classifications.
cbc.ca
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Killing cancer cells with alpha particles could be the next frontier in treatment

Canadian researchers are part of global efforts to test targeted alpha therapy, a new cancer treatment using radioactive alpha particles to kill cancer cells more effectively and with less damage to healthy tissue. Several therapies are in final stages of testing and could be approved by Health Canada within a few years. Potential applications include pancreatic, prostate, breast, and neuroendocrine cancers. Challenges include production of rare radioactive isotopes and high costs, with treatments expected to cost tens of thousands of dollars per dose.
frontiersin.org
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Editorial: Innovations in Radiotheranostics: Honoring Dr. Saul Hertz's Pioneering Legacy

Radiotheranostics merges diagnostic and therapeutic capabilities, enhancing precision medicine in oncology through radiopharmaceuticals, with potential applications in cardiology and neurology.

Prostate Cancer, Pathophysiology and Recent Developments in Management: A Narrative Review

Prostate cancer stages include localized, locally advanced, non-metastatic castration-resistant (M0 CRPCa), and metastatic disease. Treatments for M0 CRPCa and hormone-naive metastatic prostate cancer include androgen deprivation therapy with apalutamide, darolutamide, or enzalutamide. Metastatic castration-resistant treatments include sipuleucel-T, radium-223, abiraterone, enzalutamide, and cabazitaxel. New drugs like PARP inhibitors and Lutetium-177 aim to improve survival and progression-free survival, with ongoing trials for cabozantinib and chimeric-antigen receptor T-cell therapy.
showme.missouri.edu
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University of Missouri initiative to boost radioisotope production

MU expands NCA Lu-177 production for cancer therapies, solidifying MURR's role as the sole U.S. producer and a leader in radiopharmaceutical production.
tum.de
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TUM and ITM join forces for precision therapies in cancer medicine

TUM, TUM University Hospital, and ITM sign research agreement to enhance collaboration in nuclear medicine, radiopharmacy, and medical isotope technology, aiming to develop targeted cancer therapies using FRM II research reactor and ITM’s radiopharmaceutical expertise.
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