Tagraxofusp is a CD123-directed cytotoxin. It is a fusion protein composed of a human interleukin-3 (IL-3) that is genetically fused to the catalytic and translocation domains of truncated diphtheria toxin (DT) produced in Escherichia coli. Tagraxofusp received its first global approval by the FDA on December 21, 2018 as the first FDA-approved treatment for ...
Tagraxofusp is indicated for the treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN). In the US, it is approved for use in adults and pediatric patients over 2 years old. In Europe, it is only approved for use in adults.
Albert Einstein College of Medicine, Bronx, New York, United States
Dana Farber Cancer Institute, Boston, Massachusetts, United States
M.D. Anderson Cancer Center, Houston, Texas, United States
University of Pittsburgh Medical Center Presbyterian Shady Side, Pittsburgh, Pennsylvania, United States
MD Anderson Cancer Center, Houston, Texas, United States
H. Lee Moffiitt Cancer Center & Research Institute, Tampa, Florida, United States
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