Human interleukin-2

Indapta Therapeutics collaborates with Sanofi to evaluate allogeneic g-NK cell therapy, IDP-023, combined with Sarclisa in relapsed/refractory multiple myeloma patients. The phase 1 study will explore up to three dose levels of IDP-023 in combination with Sarclisa, with Indapta sponsoring the trial and Sanofi supplying the drug.

TILT Biotherapeutics presents data at ESMO-IO 2024 on personalized treatment strategies with TILT-123, an oncolytic virus, showing improved clinical trial outcomes. The study identifies immunological markers linked to better patient responses and supports the formation of immunological memory. TILT plans to advance TILT-123 into international Phase II trials for ovarian cancer, with expected Phase Ib results by H2 2025.

Aulos Bioscience announced the first patients dosed in a Phase I/II trial investigating avelumab, in combination with imneskibart and low-dose, subcutaneous aldesleukin, for non-small cell lung cancer. The trial follows a collaboration and supply agreement with Merck, evaluating the combination therapy for second-line treatment. Pre-clinical results showed strong anti-cancer activity, including complete tumour eradication.

Aulos Bioscience announced dosing of the first patient with AU-007, avelumab, and low-dose aldesleukin in a Phase 2 cohort for PD-L1+ NSCLC. This trial is a collaboration with Ares Trading S.A., a Merck KGaA subsidiary, and part of Aulos’ Phase 1/2 clinical trial of AU-007. Preliminary data from the Phase 2 cohort is expected in the first half of 2025.

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Early serum IL-2 levels on days 1 and 3 post-CAR T-cell therapy infusion predict rapid and robust CAR T-cell expansion in leukemia/lymphoma patients, outperforming IFN-γ and GM-CSF. IL-2 remains strongly linked to expansion at day 7, suggesting its potential as an early biomarker for CAR T-cell activity.

Indapta Therapeutics presented clinical data on IDP-023, an allogeneic g-NK cell therapy, showing objective responses in 5/9 patients with advanced multiple myeloma or non-Hodgkin lymphoma, at the lowest cell dose and without targeting antibodies. Preclinical data indicated enhanced migration and immune synapse formation by IDP-023, and superior cytotoxicity against solid tumor cell lines compared to conventional NK cells.