Human interleukin-2

Generic Name
Human interleukin-2
Brand Names
-
Drug Type
Biotech
Chemical Formula
-
CAS Number
-
Unique Ingredient Identifier
FNO32LO217
Background

Human interleukin-2 is under investigation in clinical trial NCT03475134 (TIL-ACT After NMA Chemo With IL-2 and Nivo Rescue in mMEL).

Associated Conditions
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Associated Therapies
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globenewswire.com
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Iovance Biotherapeutics Reports Financial Results and

Iovance Biotherapeutics reports $58.6M in 3Q24 product revenue for Amtagvi™ (Lifileucel), reaffirming $160-$165M FY24 and $450-$475M FY25 guidance. European regulatory authorities validate and accept marketing authorization applications for potential approval starting in 1H2025 for the UK and 2H2025 for EU and Canada. Enrollment accelerates in IOV-LUN-202 Phase 2 trial in post-anti-PD-1 NSCLC.
medpagetoday.com
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Weekend Warriors and Dementia; Iron Chelation and Alzheimer's; Neuro Drug Costs Rise

Weekend warrior activity linked to lower dementia risk; physical activity post-dementia diagnosis reduces mortality; deferiprone worsens early Alzheimer's; bepranemab shows mixed results; LX1001 improves APOE2 and tau biomarkers; low-dose interleukin-2 safe in Alzheimer's; out-of-pocket costs for neuro drugs rise; autism diagnoses increase; Alzheimer's GWAS data criticized; NHLPA forms CTE advisory committee; debate on reporting medically impaired drivers.
nature.com
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Automated and closed clinical-grade manufacturing protocol produces potent NK cells

The study involved ethical approval, leukapheresis for NK cell production, and adherence to GMP regulations. NK cells were manufactured using CliniMACS Prodigy, with quality control including sterility testing, cell count, and viability analysis. Cell lines and primary NK cells were isolated and cultured for cytotoxicity and degranulation assays.
pipelinereview.com
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Aulos Bioscience Presents Phase 2 Dose Selection Data for Novel IL-2 Therapeutic

AU-007 shows unique Treg reduction and longer PFS, with increased tumor-killing Teffs, differentiating it from other IL-2 therapeutics. Phase 2 efficacy and safety data to be presented.
thebrighterside.news
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Groundbreaking cancer treatment destroys advanced-stage tumors in less than 6 days

Rice University and Baylor College of Medicine researchers developed a treatment combining cytokine 'drug factory' implants and checkpoint inhibitor drugs, which eradicated advanced-stage mesothelioma tumors in mice within days. The treatment involves tiny IL-2-producing beads implanted near tumors, showing promising results in preclinical trials and paving the way for clinical trials in ovarian and mesothelioma patients.
nature.com
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Long term T cell response and safety of a tetravalent dengue vaccine in healthy children

Phase 2 open-label study in Panama and Philippines (2017-2020) evaluated TAK-003 vaccine in healthy children (4-16 years in Panama, 4-8 years in Philippines). Two-dose schedule on Days 1 and 90, with blood samples for serostatus, T cell, and NAb assessments. Primary objective: IFN-γ ELISPOT T cell response 1 month post-second dose. Secondary: T cell responses, NAb titers, seropositivity, safety up to 3 years. Post-hoc: T cell and NAb responses in virologically-confirmed dengue cases. No formal statistical hypotheses; data presented descriptively.
finance.yahoo.com
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Transgene Provides Update on Phase II Trial of Therapeutic Cancer Vaccine TG4001

Transgene's Phase II study of TG4001 in combination with avelumab did not meet the primary objective of improving progression-free survival in HPV16-positive cervical and anogenital tumors. However, a positive efficacy trend was observed in cervical cancer patients, prompting further analysis. Transgene will complete a full data analysis before deciding the future of TG4001.
biospace.com
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Aulos Bioscience to Present Promising Phase 2 Data for Novel IL-2 Therapeutic Antibody

Aulos Bioscience presents promising Phase 2 data for AU-007, an IL-2 therapeutic, in advanced solid tumors at SITC 39th Annual Meeting, showcasing safety and efficacy.
nature.com
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Non-pathogenic E. coli displaying decoy-resistant IL18 mutein boosts anti-tumor and CAR

Immune checkpoint inhibitors, CAR immune cells, natural killer cells, tumor-infiltrating lymphocytes, emerging immunotherapies, current immunotherapy in gastrointestinal malignancies, tumor-targeting bacteria, advancing clostridia, engineered Salmonella and E. coli strains, and probiotic-guided CAR-T cells are highlighted in cancer therapy research.
aacr.org
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FDA Approvals in Oncology: July-September 2024

The FDA approved 16 oncology therapies in Q3 2024, including first-in-class TCR T-cell therapy afami-cel for synovial cell sarcoma, denileukin diftitox for cutaneous T-cell lymphoma, and axatilimab-csfr for chronic graft-versus-host disease. Vorasidenib was approved for grade 2 astrocytoma or oligodendroglioma, and three EGFR-targeting therapies for non-small cell lung cancer. New formulations of atezolizumab and daratumumab with hyaluronidase were approved, along with expanded indications for durvalumab, isatuximab, and ribociclib. Selpercatinib was approved for pediatric medullary thyroid cancer, and pembrolizumab and dostarlimab-gxly received biomarker-agnostic approvals for malignant pleural mesothelioma and endometrial cancer, respectively.
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