Rogaratinib

Generic Name
Rogaratinib
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C23H26N6O3S
CAS Number
1443530-05-9
Unique Ingredient Identifier
98BSN6N516
Background

Rogaratinib is under investigation in clinical trial NCT03762122 (Rogaratinib in Patients With Advanced Pretreated Squamous-cell Non-small Cell Lung Cancer (SQCLC)).

Associated Conditions
-
Associated Therapies
-
ascopost.com
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Rogaratinib/Atezolizumab in Cisplatin-Ineligible FGFR mRNA-Overexpressing Urothelial Cancer

Rogaratinib and atezolizumab combo active in cisplatin-ineligible urothelial cancer patients overexpressing FGFR mRNA. 43% objective responses, 65% disease control. Recommended phase II dose: rogaratinib 600 mg twice daily plus atezolizumab 1,200 mg. Median PFS: 7.5 months (600 mg) vs 2.1 months (800 mg). Median OS: 16.8 months (600 mg) vs 8.3 months (800 mg).
jamanetwork.com
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Rogaratinib Plus Atezolizumab in Cisplatin-Ineligible Patients With FGFR RNA

Phase 1b study of rogaratinib (600 mg) plus atezolizumab (1200 mg) in 153 patients with advanced/metastatic urothelial carcinoma and FGFR3 mRNA overexpression shows a tolerable combination with a high objective response rate, indicating potential broad benefit for FGFR mRNA-positive patients.
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