Prednisolone acetate

Generic Name: Prednisolone acetate

Brand Names: Blephamide, Econopred Plus, Flo-pred, Pred Forte, Pred Mild, Pred-G

Drug Type: Small Molecule

Chemical Formula: C_₂₃H_₃₀O_₆

CAS Number: 52-21-1

Unique Ingredient Identifier: 8B2807733D

Background: Prednisolone acetate is a prednisolone molecule bound to an acetate functional group by an ester bond.

Prednisolone acetate was granted FDA approval in 1955.

Indication: Prednisolone acetate is indicated as an anti-inflammatory or immunosuppressive agent for allergic, dermatologic, gastrointestinal, hematologic, ophthalmologic, nervous system, renal, respiratory, rheumatologic, or infectious conditions. Prednisolone acetate is also indicated in organ transplant patients, as well as endocrine or neoplastic conditions.

Associated Conditions: Inflammation, Inflammatory Conditions, Ocular Infections, Irritations and Inflammations, Ocular Inflammation, Transplanted Organ Rejection

Associated Therapies: -

Clinical Trials

KPI-121 1% Versus Prednisolone for the Treatment of Inflammation Following Cataract Surgery in Children

Phase 3

Terminated

Conditions: Ocular Inflammation

Interventions: Drug: Prednisolone acetate
Drug: KPI-121 1%

First Posted Date: 2018-07-24

Last Posted Date: 2020-10-19

Lead Sponsor: Kala Pharmaceuticals, Inc.

Target Recruit Count: 2

Registration Number: NCT03596723

Locations: 🇺🇸
Children's Eye Care, PC, Detroit, Michigan, United States
🇺🇸
Byers Eye Institute at Stanford University, Palo Alto, California, United States
🇺🇸
Houston Eye Associates, The Woodlands, Texas, United States

and more 1 locations

Ethanol Gel Versus Steroid in Refractory Lumbar Discogenic Pain

Not Applicable

Active, not recruiting

Conditions: Lumbar Discogenic Pain (Disorder)

Interventions: Device: Ethanol gel
Drug: Prednisolone acetate

First Posted Date: 2018-01-30

Last Posted Date: 2024-08-20

Lead Sponsor: Gelscom SAS

Target Recruit Count: 83

Registration Number: NCT03415828

Locations: 🇫🇷
Hospital St-Etienne, Saint-Priest-en-Jarez, France
🇫🇷
Hospital Valence, Valence, France
🇫🇷
Hospital Pellegrin, Bordeaux, France

and more 2 locations

Use of Topical Euphrasia, a Homeopathic Remedy in Ophthalmology

Not Applicable

Withdrawn

Conditions: Iritis

Interventions: Drug: Prednisolone acetate
Drug: Euphrasia

First Posted Date: 2015-04-14

Last Posted Date: 2023-10-16

Lead Sponsor: Larkin Community Hospital

Registration Number: NCT02416128

Topical Use of Corticosteroid to Prevent Epiretinal Membrane Following Retinal Tear

Not Applicable

Completed

Conditions: Epiretinal Membrane

Interventions: Drug: Prednisolone acetate

First Posted Date: 2015-04-08

Last Posted Date: 2016-01-29

Lead Sponsor: Unity Health Toronto

Target Recruit Count: 200

Registration Number: NCT02412059

Macular Edema Nepafenac vs. Difluprednate Uveitis Trial

Phase 4

Terminated

Conditions: Uveitis
Macular Edema

Interventions: Drug: Nepafenac
Drug: Difluprednate
Drug: Prednisolone acetate

First Posted Date: 2013-09-11

Last Posted Date: 2021-01-13

Lead Sponsor: University of California, San Francisco

Target Recruit Count: 9

Registration Number: NCT01939691

Locations: 🇮🇳
Aravind Eye Hospital, Pondicherry, Tamil Nadu, India

Nepafenac Once Daily for Macular Edema - Study 2

Phase 3

Completed

Conditions: Non-Proliferative Diabetic Retinopathy
Cataract

Interventions: Other: Vehicle
Drug: Nepafenac Ophthalmic Suspension, 0.3%
Drug: Prednisolone acetate

First Posted Date: 2013-06-07

Last Posted Date: 2016-08-02

Lead Sponsor: Alcon Research

Target Recruit Count: 819

Registration Number: NCT01872611

Nepafenac Once Daily for Macular Edema - Study 1

Phase 3

Completed

Conditions: Non-Proliferative Diabetic Retinopathy
Cataract

Interventions: Drug: Nepafenac Ophthalmic Suspension, 0.3%
Other: Nepafenac vehicle
Drug: Prednisolone acetate

First Posted Date: 2013-05-14

Last Posted Date: 2016-08-03

Lead Sponsor: Alcon Research

Target Recruit Count: 881

Registration Number: NCT01853072

Efficacy of corticoïd Infiltration Via Sacro-coccygien Hiatus in Discal Sciatica

Phase 3

Terminated

Conditions: Discal Sciatica

Interventions: Drug: Prednisolone acetate
Drug: sham procedure

First Posted Date: 2011-12-01

Last Posted Date: 2014-12-02

Lead Sponsor: Nantes University Hospital

Target Recruit Count: 13

Registration Number: NCT01482897

Locations: 🇫🇷
Universitary Hospital, Nantes, Loire Atlantique, France

Comparison of Two Steroid Regimens to Prevent Transplant Rejection After Corneal Transplant (DMEK)

Phase 2

Completed

Conditions: Bullous Keratopathy
Fuchs' Dystrophy

Interventions: Drug: Fluorometholone
Drug: Prednisolone acetate

First Posted Date: 2011-10-07

Last Posted Date: 2014-09-03

Lead Sponsor: Price Vision Group

Target Recruit Count: 264

Registration Number: NCT01448213

Locations: 🇺🇸
Price Vision Group, Indianapolis, Indiana, United States
🇩🇪
University of Erlangen, Erlangen, Germany

Randomized, Masked Comparison of Bromfenac and Besifloxacin BID With Either Prednisolone BID or Loteprednol 0.5% BID for Prevention of Retinal Thickening and CME Following Phacoemulsification

Phase 4

Conditions: Pseudophakia
Cataract Surgery

Interventions: Drug: Pred Forte
Drug: Lotemax

First Posted Date: 2010-09-02

Last Posted Date: 2012-06-14

Lead Sponsor: Innovative Medical

Target Recruit Count: 100

Registration Number: NCT01193504

Locations: 🇺🇸
The Center For Excellence in Eye care, Miami, Florida, United States
🇺🇸
Harvard Eye Associates, Laguna Hills, California, United States
🇺🇸
Ophthalmic Consultants of Boston, Waltham, Massachusetts, United States

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