Melphalan flufenamide

Generic Name
Melphalan flufenamide
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C24H30Cl2FN3O3
CAS Number
380449-51-4
Unique Ingredient Identifier
F70C5K4786
Background

Melphalan flufenamide, also known as melflufen or J1, is a prodrug of melphalan. Melphalan flufenamide is more readily uptaken by cells than melphalan, and is cleaved to the active metabolite by aminopeptidases. In vitro models show that melphalan is 10 to hundreds of times more potent than melphalan. The increased potency makes melphalan flufenamide a treat...

Indication

Melphalan flufenamide is indicated in combination with dexamethasone to treat adults with relapsed or refractory multiple myeloma who have received ≥4 therapies and are refractory to at least one proteasome inhibitor, immunomodulatory agent, and anti-CD38 monoclonal antibody. The FDA has withdrawn the drug from the market for this indication following phase ...

Associated Conditions
Relapsed/Refractory Multiple Myeloma (RRMM)
Associated Therapies
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blog.dana-farber.org
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Living with Multiple Myeloma, Doctor Becomes Powerful Resource and Patient Advocate

Dr. Jim Omel, a multiple myeloma survivor, has been an advocate and expert for over 25 years, contributing invaluable insights to the DETERMINATION study on autologous stem cell transplants for newly diagnosed patients. His unique perspective as both a physician and patient has significantly impacted the trial's success and the development of tailored treatment approaches for diverse patient groups.
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