Ziftomenib

Kura Oncology, with ziftomenib for AML, is undervalued; KOMET-001 trial results due Q1 2025. Strong cash reserves and Kyowa Kirin partnership bolster potential. Safety concerns and competitive AML landscape pose risks.

ASH 2024 highlights include GSK's Blenrep Phase 3 data supporting re-market, J&J's Darzalex Faspro delaying progression in smoldering multiple myeloma, Arcellx's anito-cel showing comparable safety to Carvykti, and J&J/Legend's Carvykti improving survival outcomes. Kura Oncology's ziftomenib showed high response rates in leukemia, Eli Lilly's Jaypirca reduced disease progression risk, and Merck's zilovertamab vedotin achieved high complete response rates in lymphoma. Beam Therapeutics' BEAM-101 showed durable effects in sickle cell disease, Novo Nordisk's etavopivat reduced crises, and Bristol Myers Squibb's arlo-cel demonstrated durable responses in multiple myeloma. Galapagos' GLPG5101 showed encouraging cell therapy results, Orca Bio's Orca-T improved survival in blood cancers, and Sanofi's rilzabrutinib improved platelet response in thrombocytopenia. Regeneron's drug combo showed better disease control than Ultomiris in PNH.

Eunice S. Wang, MD, discusses combining ziftomenib with intensive induction in newly diagnosed NPM1-mutated or KMT2A-rearranged acute myeloid leukemia, based on KOMET-007 study data presented at the 2024 ASH Annual Meeting.

Johnson & Johnson seeks approval for Darzalex to treat high-risk smoldering myeloma, with AQUILA trial showing reduced risk of disease progression. GSK's Blenrep, after withdrawal, shows improved survival in DREAMM-7 trial. Emerging efforts aim to ease conditioning for genetic treatments in sickle cell disease. Kura Oncology's menin inhibitor shows promising results in AML, facing competition from J&J and Syndax. Pfizer's Oxbryta withdrawal for sickle cell disease remains unexplained.

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Oral and poster presentations on various studies in hematology, including outcomes with bispecific T-cell engagers, phase 1 results of menin-MLL inhibitors, and real-world outcomes of CAR T-cell therapy, among others, scheduled for December 7-9, 2024.

Ziftomenib, an oral selective menin inhibitor, shows promising results in treating treatment-resistant acute myeloid leukemia (AML), particularly in cases with NPM1 mutations or KMT2A rearrangements. Clinical trials indicate high complete remission rates, with manageable safety profiles and potential for combination therapies. The FDA's Breakthrough Therapy designation aims to expedite its development and review.

Kura Oncology to participate in JMP Securities Hematology and Oncology Summit on Dec 2, 2024. The company is focused on precision medicines for cancer treatment, with ziftomenib as a key drug candidate.

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