Tavokinogene telseplasmid
- Generic Name
- Tavokinogene telseplasmid
- Brand Names
- -
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 1971880-37-1
- Unique Ingredient Identifier
- MF4P7VQ2K8
- Background
Tavokinogene telseplasmid consists of a DNA Plasmid Vector Encoding IL-12.
- Associated Conditions
- -
- Associated Therapies
- -
Non-clinical evaluation of pmIL12 gene therapy for approval of the phase I clinical study
BALB/cAnNCrl mice were quarantined, shaved, and induced with CT26 tumors. Tumors were monitored until 60-70 mm³, then mice randomized into groups: naïve, CTRL, and pmIL12 GET at 0.5, 1, and 2 mg/ml. Pharmacodynamics, pharmacokinetics, and systemic toxicology were assessed, including tumor growth, transgene expression, plasmid DNA copies, and organ pathology. Statistical analysis used GraphPad Prism 9.
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