Nadunolimab

Generic Name
Nadunolimab
Brand Names
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Drug Type
Biotech
Chemical Formula
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CAS Number
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Unique Ingredient Identifier
ND296JF21I
Associated Conditions
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Associated Therapies
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Cantargia doses first subject in expanded part of CAN10's Phase I trial

Sweden-based Cantargia initiated an expanded Phase I trial of its antibody CAN10, targeting IL-1, IL-33, and IL-36 via IL-1RAP, with no safety concerns reported. The trial aims to assess long-lasting effects, potentially allowing a four-week dosing schedule, focusing on HS and systemic sclerosis. Preclinical models suggest CAN10 reduces disease development in inflammatory conditions. The company plans to advance to Phase II in 2025 and is also developing nadunolimab for oncology.
marketscreener.com
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Cantargia's Phase II results published in Clinical Cancer Research

Cantargia's phase II results for nadunolimab (CAN04) in advanced/metastatic pancreatic cancer (PDAC) published in Clinical Cancer Research. Efficacy better than expected with chemotherapy alone, especially in patients with high IL1RAP levels (median survival 14.2 months). Acceptable safety and reduced neuropathy suggest neuroprotective effect.
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