Pravastatin
- Generic Name
- Pravastatin
- Brand Names
- -
- Drug Type
- Small Molecule
- Chemical Formula
- C23H36O7
- CAS Number
- 81093-37-0
- Unique Ingredient Identifier
- KXO2KT9N0G
- Background
Pravastatin is the 6-alpha-hydroxy acid form of mevastatin. Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. It was the first statin administered as the active form and not as a prodrug. This drug was developed by Sankyo Co. Ltd.; however, the first approved pravastatin product was developed by Bristol Myers...
- Indication
Pravastatin is indicated for primary prevention of coronary events hypercholesterolemic patients without clinical evidence of coronary heart disease. Its use includes the reduction of risk on myocardial infarction, undergoing myocardial revascularization procedures and cardiovascular mortality.
...
- Associated Conditions
- Acute Coronary Events, Cardiovascular Outcomes, Coronary Artery Atherosclerosis, Death, Dysbetalipoproteinemia, Heterozygous Familial Hypercholesterolemia (HeFH), High Cholesterol, Hyperlipidemias, Mixed Dyslipidemias, Myocardial Infarction, Myocardial Revascularization, Secondary prevention cardiovascular event, Stroke, Sudden Cardiac Death, Transient Ischemic Attack, Elevation of serum triglyceride levels
- Associated Therapies
- -
STELLAR-Rosuvastatin vs. Atorvastatin, Pravastatin, Simvastatin Across Dose Ranges
- Conditions
- Interventions
- First Posted Date
- 2008-04-08
- Last Posted Date
- 2009-03-16
- Lead Sponsor
- AstraZeneca
- Target Recruit Count
- 5625
- Registration Number
- NCT00654537
Fasting Bioequivalence Study of Pravastatin Sodium 80 mg Tablets Versus Pravachol® 80 mg Tablets In Normal Healthy Subjects
- First Posted Date
- 2008-04-01
- Last Posted Date
- 2024-04-24
- Lead Sponsor
- Mylan Pharmaceuticals Inc
- Target Recruit Count
- 43
- Registration Number
- NCT00650221
- Locations
- 🇨🇦
Biovail Contract Research, Toronto, Ontario, Canada
Fed, Bioequivalence Study of Pravastatin Sodium 80 mg Tablets Versus Pravachol® 80 mg Tablets In Subjects
- First Posted Date
- 2008-04-01
- Last Posted Date
- 2024-04-24
- Lead Sponsor
- Mylan Pharmaceuticals Inc
- Target Recruit Count
- 44
- Registration Number
- NCT00648544
- Locations
- 🇨🇦
Biovail Contract Reseach, Toronto, Ontario, Canada
Safety of Red Yeast Rice for High Cholesterol in Individuals With Statin Intolerance
- Conditions
- Interventions
- First Posted Date
- 2008-03-20
- Last Posted Date
- 2010-01-18
- Lead Sponsor
- University of Pennsylvania
- Target Recruit Count
- 43
- Registration Number
- NCT00639223
- Locations
- 🇺🇸
Chestnut Hill Hospital, Philadelphia, Pennsylvania, United States
Evaluation of the Efficacy and Safety of Rosuvastatin 5 mg Versus Pravastatin 40 mg and Atorvastatin 10 mg in Type IIa and IIb Hypercholesterolaemic Patients
- Conditions
- Interventions
- First Posted Date
- 2008-03-07
- Last Posted Date
- 2013-11-26
- Lead Sponsor
- AstraZeneca
- Target Recruit Count
- 668
- Registration Number
- NCT00631189
- Locations
- 🇫🇷
Research Site, Yffiniac, France
Genetic Predictors of Variability in the Drug-drug Interaction Between Darunavir/Ritonavir and Pravastatin
- Conditions
- Interventions
- First Posted Date
- 2008-03-07
- Last Posted Date
- 2014-05-22
- Lead Sponsor
- University of Colorado, Denver
- Target Recruit Count
- 32
- Registration Number
- NCT00630734
- Locations
- 🇺🇸
University of Colorado Denver, Aurora, Colorado, United States
Pravastatin Therapy in Patients With Active Crohn's Disease: A Pilot Study
- First Posted Date
- 2008-01-24
- Last Posted Date
- 2011-03-08
- Lead Sponsor
- University of Virginia
- Target Recruit Count
- 40
- Registration Number
- NCT00599625
- Locations
- 🇺🇸
University of Virginia, Charlottesville, Virginia, United States
Single Dose Pravastatin Pharmacokinetics in Pediatric Peritoneal Dialysis Patients
- First Posted Date
- 2007-12-11
- Last Posted Date
- 2017-03-15
- Lead Sponsor
- Arkansas Children's Hospital Research Institute
- Target Recruit Count
- 7
- Registration Number
- NCT00571194
- Locations
- 🇺🇸
Arkansas Children's Hospital, Little Rock, Arkansas, United States
Yokohama Assessment of Fluvastatin, Pravastatin, Pitavastatin and Atorvastatin in Acute Coronary Syndrome (Yokohama-ACS)
- Conditions
- Interventions
- First Posted Date
- 2007-10-26
- Last Posted Date
- 2010-02-17
- Lead Sponsor
- Yokohama City University Medical Center
- Target Recruit Count
- 200
- Registration Number
- NCT00549926
- Locations
- 🇯🇵
Yokohama City University Medical Center, Yokohama, Japan
Pravastatin Efficacy and Safety Trial in Hypercholesterolemic Patients With Chronic Liver Disease
- Conditions
- First Posted Date
- 2007-09-14
- Last Posted Date
- 2011-04-25
- Lead Sponsor
- Bristol-Myers Squibb
- Target Recruit Count
- 232
- Registration Number
- NCT00529178
Drug Development Updates
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