Losartan is an angiotensin II receptor blocker (ARB) used to treat hypertension. Angiotensin-converting enzyme (ACE) inhibitors are used for a similar indication but are associated with a cough. When patients with ACE inhibitor associated coughs are switched to ARBs like losartan, they have an incidence of cough similar to placebo or hydrochlorothiazide. Losartan is available as losartan potassium oral tablets as well as a combination tablet of losartan potassium and hydrochlorothiazide. Patients taking losartan should have their renal function and potassium levels monitored. Losartan was granted FDA approval on 14 April 1995.
Losartan is indicated to treat hypertension in patients older than 6 years, reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy (though this benefit may not extend to patients with African heritage), and to treat diabetic nephropathy with elevated serum creatinine and proteinuria in patients with type 2 diabetes and hypertension. Losartan with hydrochlorothiazide is indicated to treat hypertension and to reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy (though this benefit may not extend to patients with African heritage).
Novartis Investigative Site, Santander, Spain
Massachusetts General Hospital, Boston, Massachusetts, United States
Queen Mary Hospital, Hong Kong, China
Hospital 12 de Octubre, Madrid, Spain
Hospital Vall d'Hebron, Barcelona, Spain
Anapharm Inc., Sainte-Foy, Quebec, Canada
Anapharm Inc., Montreal, Quebec, Canada
Clinical Reserach Center, UCSF, San Francisco,, California, United States
Queen Elizabeth Hospital, Birmingham, United Kingdom
Plymouth Hospitals NHS Trust, Plymouth, Devon, United Kingdom
Royal Derby Hospital, Derby, United Kingdom
Diabetes Center, Institute of Clinical and Experimental Medicine, Prague, Czech Republic
University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States
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