Losartan

Generic Name
Losartan
Brand Names
Hyzaar, Cozaar
Drug Type
Small Molecule
Chemical Formula
C22H23ClN6O
CAS Number
114798-26-4
Unique Ingredient Identifier
JMS50MPO89
Background

Losartan is an angiotensin II receptor blocker (ARB) used to treat hypertension. Angiotensin-converting enzyme (ACE) inhibitors are used for a similar indication but are associated with a cough. When patients with ACE inhibitor associated coughs are switched to ARBs like losartan, they have an incidence of cough similar to placebo or hydrochlorothiazide. Los...

Indication

Losartan is indicated to treat hypertension in patients older than 6 years, reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy (though this benefit may not extend to patients with African heritage), and to treat diabetic nephropathy with elevated serum creatinine and proteinuria in patients with type 2 diabetes and hyper...

Associated Conditions
Diabetic Nephropathy, Ventricular Dysfunction, Hypertension, Marfan Syndrome, Ischemic Stroke
Associated Therapies
-

Losartan for Improved Vascular Endothelial Function After Preeclampsia

Early Phase 1
Recruiting
Conditions
Interventions
First Posted Date
2020-11-17
Last Posted Date
2024-08-16
Lead Sponsor
Anna Stanhewicz, PhD
Target Recruit Count
20
Registration Number
NCT04632589
Locations
🇺🇸

University of Iowa, Iowa City, Iowa, United States

The Effects of Losartan on Emotion Processing

Not Applicable
Conditions
Interventions
First Posted Date
2020-10-28
Last Posted Date
2020-10-28
Lead Sponsor
University of Electronic Science and Technology of China
Target Recruit Count
90
Registration Number
NCT04606212
Locations
🇨🇳

University of Electronic Science and Technology of China, Chengdu, Sichuan, China

Losartan Effects on Emotion-memory Interaction

Not Applicable
Conditions
Interventions
First Posted Date
2020-10-28
Last Posted Date
2020-10-28
Lead Sponsor
University of Electronic Science and Technology of China
Target Recruit Count
60
Registration Number
NCT04606225
Locations
🇨🇳

University of Electronic Science and Technology of China, Chengdu, Sichuan, China

Host Response Mediators in Coronavirus (COVID-19) Infection - Is There a Protective Effect of Losartan and Other ARBs on Outcomes of Coronavirus Infection?

First Posted Date
2020-10-28
Last Posted Date
2023-02-16
Lead Sponsor
University of British Columbia
Target Recruit Count
341
Registration Number
NCT04606563
Locations
🇨🇦

Royal Jubilee Hospital, Nanaimo, British Columbia, Canada

🇨🇦

St Paul's Hospital, Vancouver, British Columbia, Canada

🇨🇦

The Ottawa Hospital, Ottawa, Ontario, Canada

and more 10 locations

The Effects of Losartan on Social Reward

Not Applicable
Conditions
Interventions
First Posted Date
2020-10-27
Last Posted Date
2020-10-27
Lead Sponsor
University of Electronic Science and Technology of China
Target Recruit Count
90
Registration Number
NCT04604756
Locations
🇨🇳

University of Electronic Science and Technology of China, Chengdu, Sichuan, China

The Effects of Losartan on Reward Reinforcement Learning

Not Applicable
Conditions
Interventions
First Posted Date
2020-10-27
Last Posted Date
2020-10-27
Lead Sponsor
University of Electronic Science and Technology of China
Target Recruit Count
60
Registration Number
NCT04604938
Locations
🇨🇳

University of Electronic Science and Technology of China, Chengdu, Sichuan, China

Metformin's Effect on Drug Metabolism in Patients With Type 2 Diabetes

First Posted Date
2020-08-07
Last Posted Date
2022-06-16
Lead Sponsor
University of Southern Denmark
Target Recruit Count
10
Registration Number
NCT04504045
Locations
🇩🇰

University of Southern Denmark, Odense, Region Of Southern Denmark, Denmark

Early Treatment With Ivermectin and LosarTAN for Cancer Patients With COVID-19 Infection

First Posted Date
2020-06-25
Last Posted Date
2022-08-09
Lead Sponsor
Instituto do Cancer do Estado de São Paulo
Target Recruit Count
77
Registration Number
NCT04447235
Locations
🇧🇷

Instituto do Cancer do Estado de Sao Paulo, SAo Paulo, Brazil

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