Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According t...
For use in combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation for chronic myelogenous (myeloid, myelocytic, granulocytic) leukemia (FDA has designated busulfan as an orphan drug for this use). It is also used as a component of pretransplant conditioning regimens in patients undergoing...
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States
University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States
University of Arkansas for Medical Sciences, Myeloma Institute for Research and Therapy, Little Rock, Arkansas, United States
Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States
Jonsson Comprehensive Cancer Center at UCLA, Los Angeles, California, United States
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States
North Shore University Hospital, Manhasset, New York, United States
Nemours Children's Clinic, Jacksonville, Florida, United States
Cardinal Glennon Children's Hospital, Saint Louis, Missouri, United States
Hackensack University Medical Center, Hackensack, New Jersey, United States
St. Christopher's Hospital for Children, Philadelphia, Pennsylvania, United States
University of Florida Health Science Center, Gainesville, Florida, United States
University of Texas - MD Anderson Cancer Center, Houston, Texas, United States
Hospitais da Universidade de Coimbra (HUC), Coimbra, Portugal
Institute of Hematology and Blood Transfusion, Prague, Czech Republic
Algemeen Ziekenhuis Middelheim, Antwerp, Belgium
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