Hydromorphone
- Generic Name
- Hydromorphone
- Brand Names
- Dilaudid, Exalgo, Hydromorph Contin, Hydromorphone Hp Forte
- Drug Type
- Small Molecule
- Chemical Formula
- C17H19NO3
- CAS Number
- 466-99-9
- Unique Ingredient Identifier
- Q812464R06
- Background
Hydromorphone is a pure opioid, a semi-synthetic hydrogenated ketone derivative of morphine that has been available clinically since 1920. Structurally, hydromorphone derived from morphine in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 and 8. Due to these modifications, it present...
- Indication
Hydromorphone is indicated for the management of moderate to severe acute pain and severe chronic pain. Due to its addictive potential and overdose risk, hydromorphone is only prescribed when other first-line treatments have failed.
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- Associated Conditions
- Neuropathic Pain, Refractory Chronic Cough, Moderate to severe pain
- Associated Therapies
- -
Prospective Longitudinal Observational Study to Evaluate the Clinical Characteristics and Opioids Treatments in Patients With Breakthrough Cancer Pain
- First Posted Date
- 2013-09-19
- Last Posted Date
- 2016-04-14
- Target Recruit Count
- 150
- Registration Number
- NCT01946555
- Locations
- 🇮🇹
A.O. Universitaria Parma, Parma, Italia, Italy
🇮🇹Ospedale di Piacenza, Piacenza, Italy
🇮🇹Ospedale Magati, Scandiano, Italia, Italy
Titration of Intravenous Hydromorphone
- First Posted Date
- 2013-07-04
- Last Posted Date
- 2023-05-31
- Lead Sponsor
- Montefiore Medical Center
- Target Recruit Count
- 215
- Registration Number
- NCT01892709
- Locations
- 🇺🇸
Montefiore Medical Center Moses Emegency Department, Bronx, New York, United States
Use of Intrathecal Hydromorphone in Elective Cesarean Deliveries
- First Posted Date
- 2013-05-31
- Last Posted Date
- 2019-01-03
- Lead Sponsor
- Grace Shih, MD
- Target Recruit Count
- 45
- Registration Number
- NCT01866254
- Locations
- 🇺🇸
University of Kansas Medical Center, Kansas City, Kansas, United States
A Pharmacokinetic and Safety Study of Osmotic Release Oral System (OROS) Hydromorphone in Non-Opioid Tolerant Chinese Participants With Cancer
- First Posted Date
- 2013-04-04
- Last Posted Date
- 2014-08-15
- Lead Sponsor
- Xian-Janssen Pharmaceutical Ltd.
- Target Recruit Count
- 12
- Registration Number
- NCT01824524
Study of Respiratory Depression When Using a Hydromorphone Pain Protocol
- Conditions
- Interventions
- First Posted Date
- 2013-02-06
- Last Posted Date
- 2020-03-19
- Lead Sponsor
- Albert Einstein Healthcare Network
- Target Recruit Count
- 116
- Registration Number
- NCT01784991
- Locations
- 🇺🇸
Albert Einstein Medical Center, Philadelphia, Pennsylvania, United States
Association Between Body Size and Response to Hydromorphone in ED
- First Posted Date
- 2012-08-30
- Last Posted Date
- 2020-10-08
- Lead Sponsor
- Albert Einstein College of Medicine
- Target Recruit Count
- 174
- Registration Number
- NCT01675778
- Locations
- 🇺🇸
North Central Bronx Hospital, Bronx, New York, United States
🇺🇸Jacobi Medical Center, Bronx, New York, United States
Study of the Treatment of Experimental Pain in Opioid Dependent Persons on Methadone or Buprenorphine Maintenance
- Conditions
- Interventions
- First Posted Date
- 2012-07-17
- Last Posted Date
- 2017-09-11
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 132
- Registration Number
- NCT01642030
- Locations
- 🇺🇸
Behavioral Pharmacology Research Unit, Baltimore, Maryland, United States
Hydromorphone and C-section
- First Posted Date
- 2012-05-15
- Last Posted Date
- 2014-12-17
- Lead Sponsor
- Emory University
- Target Recruit Count
- 20
- Registration Number
- NCT01598545
- Locations
- 🇺🇸
Grady Memorial Hospital, Atlanta, Georgia, United States
Intrathecal Hydromorphone for Labor Analgesia
- First Posted Date
- 2012-05-15
- Last Posted Date
- 2018-01-12
- Lead Sponsor
- Emory University
- Target Recruit Count
- 22
- Registration Number
- NCT01598506
- Locations
- 🇺🇸
Grady Memorial Hospital, Atlanta, Georgia, United States
Intraoperative Opioids and Postoperative Recovery After Hepatobiliary or Foregut Surgery
- First Posted Date
- 2012-03-07
- Last Posted Date
- 2021-12-21
- Lead Sponsor
- NorthShore University HealthSystem
- Target Recruit Count
- 60
- Registration Number
- NCT01546948
- Locations
- 🇺🇸
NorthShore University HealthSystem, Evanston, Illinois, United States
Drug Development Updates
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