Disulfiram
- Generic Name
- Disulfiram
- Brand Names
- Antabuse
- Drug Type
- Small Molecule
- Chemical Formula
- C10H20N2S4
- CAS Number
- 97-77-8
- Unique Ingredient Identifier
- TR3MLJ1UAI
Overview
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Background
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Indication
For the treatment and management of chronic alcoholism
Associated Conditions
- Chronic Alcoholism
Clinical Trials
FDA Approved Products
Singapore Approved Products
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