Disulfiram
- Generic Name
- Disulfiram
- Brand Names
- Antabuse
- Drug Type
- Small Molecule
- Chemical Formula
- C10H20N2S4
- CAS Number
- 97-77-8
- Unique Ingredient Identifier
- TR3MLJ1UAI
- Background
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nau...
- Indication
For the treatment and management of chronic alcoholism
- Associated Conditions
- Chronic Alcoholism
- Associated Therapies
- -
Disulfiram in Treating Patients With Glioblastoma Multiforme After Radiation Therapy With Temozolomide
- Conditions
- Interventions
- First Posted Date
- 2013-07-24
- Last Posted Date
- 2018-07-20
- Lead Sponsor
- Washington University School of Medicine
- Target Recruit Count
- 21
- Registration Number
- NCT01907165
- Locations
- πΊπΈ
Washington University School of Medicine, Saint Louis, Missouri, United States
Disulfiram/Copper Combination In The Treatment of Newly Diagnosed Glioblastoma Multiform
- First Posted Date
- 2013-01-29
- Last Posted Date
- 2016-10-17
- Lead Sponsor
- Olympion Medical Center
- Target Recruit Count
- 32
- Registration Number
- NCT01777919
- Locations
- π¬π·
Olympion Medical Center, Patras, Greece
Short-term Disulfiram Administration to Accelerate the Decay of the HIV Reservoir in Antiretroviral-treated HIV Infected Individuals
- First Posted Date
- 2011-01-31
- Last Posted Date
- 2020-06-30
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 16
- Registration Number
- NCT01286259
- Locations
- πΊπΈ
Johns Hopkins University, Baltimore, Maryland, United States
πΊπΈSan Francisco General Hospital, San Francisco, California, United States
Study of Recurrent Prostate Cancer With Rising Prostate Specific Antigen (PSA)
- Conditions
- First Posted Date
- 2010-05-07
- Last Posted Date
- 2018-06-12
- Target Recruit Count
- 19
- Registration Number
- NCT01118741
- Locations
- πΊπΈ
Johns Hopkins Hospital, Baltimore, Maryland, United States
πΊπΈThomas Jefferson Universith, Philadelphia, Pennsylvania, United States
πΊπΈDuke University, Durham, North Carolina, United States
Disulfiram for Cocaine Abuse in Buprenorphine Treatment
- Conditions
- Interventions
- First Posted Date
- 2009-06-04
- Last Posted Date
- 2020-11-19
- Lead Sponsor
- Yale University
- Target Recruit Count
- 177
- Registration Number
- NCT00913484
- Locations
- πΊπΈ
The APT Foundation MRU, New Haven, Connecticut, United States
πΊπΈYale University School of Medicine, New Haven, Connecticut, United States
Disulfiram Interactions With HIV Medications: Clinical Implications
- Conditions
- Interventions
- First Posted Date
- 2009-04-08
- Last Posted Date
- 2014-05-06
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 40
- Registration Number
- NCT00878306
- Locations
- πΊπΈ
San Francisco General Hospital, San Francisco, California, United States
Phase I Study of Disulfiram and Copper Gluconate for the Treatment of Refractory Solid Tumors Involving the Liver
- First Posted Date
- 2008-08-28
- Last Posted Date
- 2014-10-31
- Lead Sponsor
- University of Utah
- Target Recruit Count
- 21
- Registration Number
- NCT00742911
- Locations
- πΊπΈ
Huntsman Cancer Institute, Salt Lake City, Utah, United States
Open-Label Disulfiram for Methamphetamine Dependence
- First Posted Date
- 2008-08-08
- Last Posted Date
- 2012-02-27
- Lead Sponsor
- University of Arkansas
- Target Recruit Count
- 15
- Registration Number
- NCT00731133
- Locations
- πΊπΈ
University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States
A Study of the Relationship Between Disulfiram and Cocaine Self-administration.
- First Posted Date
- 2008-08-07
- Last Posted Date
- 2023-07-19
- Lead Sponsor
- Baylor College of Medicine
- Target Recruit Count
- 52
- Registration Number
- NCT00729300
- Locations
- πΊπΈ
Baylor College of Medicine, Houston, Texas, United States
Clinical Efficacy of Disulfiram in LAAM-Maintained Cocaine Abusers
- Conditions
- Interventions
- First Posted Date
- 2007-12-27
- Last Posted Date
- 2020-03-31
- Lead Sponsor
- Yale University
- Target Recruit Count
- 126
- Registration Number
- NCT00580827
- Locations
- πΊπΈ
West Haven VA, West Haven, Connecticut, United States
Drug Development Updates
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