Overview
A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.
Indication
Used to treat vitamin C deficiency, scurvy, delayed wound and bone healing, urine acidification, and in general as an antioxidant. It has also been suggested to be an effective antiviral agent.
Associated Conditions
- Common Cold
- Deficiency, Vitamin A
- Deficiency, Vitamin D
- Fever
- Flu caused by Influenza
- Folate deficiency
- Iron Deficiency (ID)
- Iron Deficiency Anemia (IDA)
- Oral bacterial infection
- Scurvy
- Vitamin C Deficiency
- Vitamin Deficiency
Research Report
A Comprehensive Monograph on L-Ascorbic Acid (Vitamin C): From Chemical Structure to Clinical Application
Introduction and Historical Context: The Conquest of Scurvy and the Identification of a Vital Molecule
Overview of L-Ascorbic Acid
L-ascorbic acid, universally known as Vitamin C, is an essential water-soluble vitamin and a small molecule drug cataloged under DrugBank ID DB00126.[1] It is a six-carbon compound structurally analogous to glucose, which is indispensable for human health.[1] Unlike most vertebrates, humans lack the enzyme L-gulonolactone oxidase, which catalyzes the final step in ascorbic acid biosynthesis, making it an essential nutrient that must be obtained exogenously through diet.[3] Its fundamental physiological roles are vast and critical, encompassing the maintenance of connective tissue and bone, functioning as a primary reducing agent and coenzyme in numerous metabolic pathways, and serving as one of the body's most potent and vital antioxidants.[1]
The Historical Scourge of Scurvy
Clinical Trials
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Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2016/08/16 | Phase 2 | Completed | |||
2016/07/20 | Not Applicable | UNKNOWN | |||
2016/06/14 | Not Applicable | Completed | qinshaozheng | ||
2016/06/08 | Phase 2 | Completed | Yolanda de Diego Otero | ||
2016/05/23 | Phase 4 | Completed | |||
2016/05/04 | Phase 1 | Terminated | |||
2016/04/20 | Phase 2 | Completed | |||
2016/04/13 | Phase 3 | Recruiting | |||
2016/04/12 | Phase 2 | Terminated | |||
2016/01/14 | Phase 1 | Completed | Clifford Hospital, Guangzhou, China |
FDA Drug Approvals
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Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| Pangea Pharmaceuticals, LLC | 81279-101 | ORAL | 36 mg in 1 mL | 12/22/2023 | |
| PureTek Corporation | 59088-017 | ORAL | 24 mg in 1 1 | 5/2/2025 | |
| PureTek Corporation | 59088-162 | ORAL | 50 mg in 1 1 | 4/1/2024 | |
| Avion Pharmaceuticals, LLC | 75854-315 | ORAL | 60 mg in 1 1 | 1/7/2021 | |
| BonGeo Pharmaceuticals, Inc. | 52796-177 | ORAL | 75 mg in 1 1 | 2/1/2024 | |
| PureTek Corporation | 59088-108 | ORAL | 24 mg in 1 1 | 9/2/2022 | |
| Bryant Ranch Prepack | 63629-1136 | ORAL | 60 mg in 1 1 | 12/30/2021 | |
| Nephro-Tech, Inc. | 59528-0317 | ORAL | 60 mg in 1 1 | 7/13/2021 | |
| Acella Pharmaceuticals, LLC | 42192-323 | ORAL | 28 mg in 1 1 | 9/11/2018 | |
| Parasitology Center, Inc. | 70321-0002 | ORAL | 6 [hp_C] in 1 mL | 5/22/2025 |
EMA Drug Approvals
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| No EMA approvals found for this drug. | |||
HSA Drug Approvals
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|---|---|---|---|---|---|
| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
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|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
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Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
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| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
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Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| GO Zinc Complex | 455086 | Medicine | A | 7/11/2024 | |
| Princess Luna Liver Detox Max Plus | 448830 | Medicine | A | 5/16/2024 | |
| Daily Multi Multivitamin | 443352 | Medicine | A | 3/7/2024 | |
| ETHICAL NUTRIENTS SUPER B DAILY STRESS + | 441996 | Medicine | A | 2/22/2024 | |
| Mother Dose | 487175 | Medicine | A | 4/30/2025 | |
| Amcal Collagen Plus Skin | 465224 | Medicine | A | 10/22/2024 | |
| BLACKMORES JOINT MOBILITY PLUS | 464115 | Medicine | A | 10/11/2024 | |
| Microgenics Marine Collagen Beauty Complex | 459207 | Medicine | A | 8/12/2024 | |
| Performance Plus Apple+Berry | 450567 | Medicine | A | 6/3/2024 | |
| Guardian Vitamin C Orange Flavour Effervescent | 450625 | Medicine | A | 6/3/2024 |
Health Canada Drug Approvals
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Approved Product | Company | DIN | Dosage Form | Strength | Market Date |
|---|---|---|---|---|---|
| ONESOURCE | perrigo international | 02238021 | Tablet - Oral | 100 MG / TAB | 7/31/1998 |
| ZINC-C LOZENGES | twin laboratories inc. | 01983709 | Lozenge - Oral | 30 MG / LOZ | 12/31/1995 |
| ADVANCED B & T FORMULA | nutraceutical corporation | 02240717 | Capsule - Oral | 33.3 MG | N/A |
| ONE A DAY ADVANCE - ADULTS 50 + - TABS | bayer inc consumer care | 02155206 | Tablet - Oral | 120 MG | 12/31/1996 |
| OSTEO-FORCE | prairie naturals | 02236700 | Capsule - Oral | 25 MG / CAP | 10/17/1997 |
| TIANSHI BENEFICIAL CAPSULES | tianjin tianshi group co., ltd. | 02241261 | Capsule - Oral | 8 MG / CAP | N/A |
| VITAMINE C TAB 100MG MASTICABLES | laboratoire lalco inc. | 00495417 | Tablet - Oral | 100 MG / TAB | 12/31/1980 |
| VITAMIN C TABLETS TIME RELEASE 1000MG | international nutrition ltd. | 02138727 | Tablet (Extended-Release) - Oral | 1 G / SRT | 7/26/1996 |
| VITAMIN C TAB 500MG | nutristar health products (1987) inc. | 00471054 | Tablet - Oral | 500 MG / TAB | 12/31/1979 |
| STRESS FORMULA | vita health products inc | 02236417 | Tablet - Oral | 500 MG / TAB | 5/20/1998 |
CIMA AEMPS Drug Approvals
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| No CIMA AEMPS (Spain) approvals found for this drug. | |||||
Philippines FDA Drug Approvals
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| No Philippines FDA approvals found for this drug. | |||||
Saudi SFDA Drug Approvals
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| No Saudi SFDA approvals found for this drug. | |||||
Malaysia NPRA Drug Approvals
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| No Malaysia NPRA approvals found for this drug. | |||||
UK EMC Drug Information
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| No UK EMC drug information found for this drug. | |||||
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